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Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action
Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action
- Source :
- Diabetologia. 49:343-350
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- We studied the impact of genetic versus pre- and postnatal environmental factors on the plasma levels of IL6, TNF and the soluble TNF receptor superfamily, member 1A (TNFRSF1A, previously known as TNF receptor type1 [TNFR1]). Using the hyperinsulinaemic–euglycaemic clamp, we assessed the association between cytokine levels and both peripheral insulin sensitivity and hepatic glucose production. Fasting plasma IL6, TNF and soluble TNFRSF1A levels were measured using ELISA in 55 young and 43 elderly twin pairs. Plasma IL6 and TNF were influenced by genetic factors in young and elderly twins respectively, while no significant impact of genetics was found for soluble TNFRSF1A. Significant intra-twin pair correlations between birthweight and both IL6 and soluble TNFRSF1A levels were found. In addition to the effect of birthweight on IL6, age and fat % also significantly influenced IL6 levels, whereas soluble TNFRSF1A levels were significantly influenced by zygosity, age, fat % and sex. Plasma soluble TNFRSF1A was associated with higher plasma NEFA and to some extent with reduced insulin sensitivity. Plasma IL6 was associated positively with basal NEFA. TNF level was not associated with in vivo glucose or fat metabolism after correction for known confounders. Plasma IL6 and soluble TNFRSF1A are influenced by the intrauterine environment. We found some evidence of a genetic component for TNF and IL6 in young and elderly twins respectively. Plasma IL6 may influence basal lipolysis, but neither plasma TNF nor IL6 levels are independently associated with hepatic or peripheral insulin action. Nevertheless, plasma soluble TNFRSF1A may play some role in the control of insulin action.
- Subjects :
- Adult
Male
Aging
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Enzyme-Linked Immunosorbent Assay
Type 2 diabetes
Fatty Acids, Nonesterified
Biology
Insulin resistance
NEFA
Pregnancy
Internal medicine
Twins, Dizygotic
Internal Medicine
medicine
Birth Weight
Humans
Insulin
Lipolysis
Pancreatic hormone
Aged
Sex Characteristics
Interleukin-6
Tumor Necrosis Factor-alpha
Twins, Monozygotic
Middle Aged
Glucose clamp technique
medicine.disease
Glucose
Cytokine
Endocrinology
Liver
Receptors, Tumor Necrosis Factor, Type I
Glucose Clamp Technique
Female
Insulin Resistance
Subjects
Details
- ISSN :
- 14320428 and 0012186X
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....ae42e65bca3aaad2a3409d5125f550de
- Full Text :
- https://doi.org/10.1007/s00125-005-0080-8