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Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor
- Source :
- International Journal of Gynecology & Obstetrics. 113:192-195
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Objective To compare the effectiveness and adverse effects of nifedipine versus indomethacin in the treatment of preterm labor. Methods In a randomized clinical trial, 79 women with labor pain at 26–33 weeks of gestation were treated with either oral nifedipine (n = 40) or rectal indomethacin (n = 39). Results Twenty-three (59%) women in the indomethacin group, and 10 (25%) in the nifedipine group did not respond to treatment (P = 0.002). None of the 16 and 30 women remaining in the indomethacin and nifedipine groups, respectively, delivered during the subsequent 48 hours. Of these remaining women, 1 (6.25%) in the indomethacin group and 4 (13.3%) in the nifedipine group delivered between 48 hours and 7 days (P = 0.162). For the women who responded to treatment, the mean gestational age at time of delivery was 238.5 ± 19.4 days and 246.4 ± 15.4 days in the nifedipine and indomethacin groups, respectively (P = 0.182). Seventeen (42.5%) women in the nifedipine group, and 11 (28.2%) in the indomethacin group showed adverse effects (P = 0.184). Conclusion Indomethacin was less effective than nifedipine for the fast treatment of preterm labor. For women who responded to treatment within 2 hours, however, the delaying of delivery by indomethacin was similar to that by nifedipine.
- Subjects :
- Adult
Tocolytic agent
Nifedipine
Preterm labor
Indomethacin
Drug Administration Schedule
law.invention
Obstetric Labor, Premature
Randomized controlled trial
Indometacin
Pregnancy
law
medicine
Humans
Adverse effect
business.industry
Obstetrics and Gynecology
Gestational age
Labor pain
General Medicine
medicine.disease
Tocolytic Agents
Treatment Outcome
Premature birth
Anesthesia
Tocolytic
Prostaglandin inhibitor
Premature Birth
Gestation
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00207292
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- International Journal of Gynecology & Obstetrics
- Accession number :
- edsair.doi.dedup.....ae4a5f799c041d42862a87327b501818