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The use of nasal allergen vs allergen exposure chambers to evaluate allergen immunotherapy
- Source :
- Expert review of clinical immunology. 17(5)
- Publication Year :
- 2021
-
Abstract
- Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment option for allergic rhinitis (AR) patients with persistent moderate-severe AR for whom traditional pharmacotherapies are ineffective. The nasal allergen challenge (NAC) and allergen exposure chamber (AEC) are two translational models of AR that can be used to investigate the properties, safety, and efficacy of AIT.Peer-reviewed, human-centered articles utilizing AEC or NAC models to investigate AIT between 2010 and 2020 were curated from PubMed, EMBASE, and OVID Medline databases. AECs have been used to evaluate traditional subcutaneous and sublingual administrations of AIT, including cross-protective effects and different dosing regimens. More recently, the effectiveness of novel AIT formulations has been evaluated. NACs are another model used to study AIT, including using novel intralymphatic routes of administration. It is an especially powerful and versatile tool to determine if basic science and animal model findings are clinically translatable.The AEC and NAC models both produce clinically relevant and reproducible results. AECs are more effective for studying many participants but are limited because they require a specialized facility. As more AIT therapies and new formulations are developed over time, the versatility of the NAC will be especially useful.
- Subjects :
- 030203 arthritis & rheumatology
0301 basic medicine
Allergen immunotherapy
Nasal Provocation Tests
business.industry
medicine.medical_treatment
Immunology
Administration, Sublingual
Treatment options
Immunotherapy
Allergens
medicine.disease_cause
Rhinitis, Allergic
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Allergen
Desensitization, Immunologic
medicine
Immunology and Allergy
Animals
Humans
ALLERGEN EXPOSURE
business
Subjects
Details
- ISSN :
- 17448409
- Volume :
- 17
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Expert review of clinical immunology
- Accession number :
- edsair.doi.dedup.....ae51e9b086c3a6e8d8145c5d4075916b