Back to Search
Start Over
Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine
- Source :
- Vaccine. 33:1433-1439
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Cytomegalovirus (CMV)-seropositivity has been shown to have a negative effect on influenza vaccine-specific antibody responses. In this paper, we confirm and extend these results showing for the first time, a negative association between CMV-seropositivity and B cell predictive biomarkers of optimal vaccine responses. These biomarkers are switched memory B cells and AID in CpG-stimulated B cell cultures measured before vaccination which positively correlate with the serum response to the influenza vaccine. We also found that CMV-seropositivity is associated with increased levels of B cell-intrinsic inflammation and these both correlate with lower B cell function. Finally, CMV-seropositivity is associated with decreased percentages of individuals responding to the vaccine in both young and elderly individuals.
- Subjects :
- Adult
Male
Aging
Influenza vaccine
Congenital cytomegalovirus infection
Cytomegalovirus
Inflammation
Negative association
Biology
Antibodies, Viral
Article
Young Adult
medicine
Humans
Serologic Tests
B cell
Aged
Predictive biomarker
Aged, 80 and over
B-Lymphocytes
General Veterinary
General Immunology and Microbiology
Vaccination
Public Health, Environmental and Occupational Health
virus diseases
Middle Aged
medicine.disease
Virology
Infectious Diseases
Antibody response
medicine.anatomical_structure
Influenza Vaccines
Cytomegalovirus Infections
Immunology
Molecular Medicine
Female
medicine.symptom
Immunologic Memory
Biomarkers
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....ae52db4e99b620256ec7591b2d2be182