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Lithium treatment in bipolar adolescents: a follow-up naturalistic study
- Source :
- Neuropsychiatric Disease and Treatment
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Gabriele Masi,1 Annarita Milone,1 Giulia Scrinzi,2 Maria Mucci,1 Valentina Viglione,1 Gabriella Bruni,1 Stefano Berloffa,1 Simone Pisano3 1IRCCS Stella Maris Foundation, Developmental Psychiatry and Psychopharmacology Unit, Pisa, Italy; 2Child Neuropsychiatry Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy; 3Clinic of Child and Adolescent Neuropsychiatry, Department of Medicine and Surgery, University of Salerno, Salerno, Italy Background: Although lithium is currently approved for the treatment of bipolar disorders in youth, long term data, are still scant. The aim of this study was to describe the safety and efficacy of lithium in referred bipolar adolescents, who were followed up at the 4th (T1) and 8th (T2) month of treatment.Methods: The design was naturalistic and retrospective, based on a clinical database, including 30 patients (18 males, mean age 14.2±2.1 years).Results: Mean blood level of lithium was 0.69±0.20 mEq/L at T1 and 0.70±0.18 mEq/L at T2. Both Clinical Global Impression-Severity (CGI-S) and Children Global Assessment Scale (C-GAS) scores improved from baseline (CGI-S 5.7±0.5, C-GAS 35.1±3.7) to T1 (CGI-S 4.2±0.70, C-GAS 46.4±6.5; P
- Subjects :
- safety
medicine.medical_specialty
Neuropsychiatric Disease and Treatment
Lithium (medication)
Sedation
QT interval
Gastroenterology
03 medical and health sciences
0302 clinical medicine
White blood cell
Internal medicine
medicine
0501 psychology and cognitive sciences
adolescents
Bipolar disorder
Original Research
bipolar disorder
business.industry
05 social sciences
Thyroid
medicine.disease
3. Good health
030227 psychiatry
medicine.anatomical_structure
lithium
adolescent
Long term data
medicine.symptom
business
050104 developmental & child psychology
Hormone
medicine.drug
Subjects
Details
- ISSN :
- 11782021
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Neuropsychiatric Disease and Treatment
- Accession number :
- edsair.doi.dedup.....ae6526a68534cba00908d2728f67d131