Back to Search
Start Over
Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts
- Source :
- British Journal of Cancer
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- We examined the associations of body mass index (BMI), waist circumference, a history of diabetes, and cigarette smoking with risk of pancreatic cancer among 37,147 women and 45,906 men followed up during 560,666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men; 136 incident cases of pancreatic cancer were diagnosed. The multivariate rate ratio (RR) of pancreatic cancer for obese women and men (BMI > or =30 kg/m(2)) was 1.81 (95% CI: 1.04-3.15) compared to those with a BMI of 20-25 kg/m(2). For a difference of 20 cm (about two standard deviations) in waist circumference, the multivariate RRs were 1.32 (95% CI: 0.73-2.37) among women and 1.74 (95% CI: 1.00-3.01) among men. Pancreatic cancer risk was associated with history of diabetes (multivariate RR: 1.88; 95% CI: 1.09-3.26) and cigarette smoking (multivariate RR for current compared with never smokers: 3.06; 95% CI: 1.99-4.72). Current smokers of > or =40 pack-years had a five-fold elevated risk compared with never smokers. Risk among past smokers approached the RR for never smokers within 5-10 years following smoking cessation. Findings from this prospective study support positive relationships of overall obesity, abdominal adiposity, diabetes and smoking with risk of pancreatic cancer.
- Subjects :
- Adult
Male
obesity
Cancer Research
medicine.medical_specialty
Waist
Epidemiology
medicine.medical_treatment
Abdominal Fat
body mass index
Rate ratio
smoking
Cohort Studies
Diabetes Complications
Sex Factors
Risk Factors
Internal medicine
medicine
Humans
Risk factor
Prospective cohort study
Aged
Aged, 80 and over
Sweden
anthropometry
business.industry
pancreatic neoplasms
Middle Aged
prospective studies
smoking cessation
Surgery
Oncology
diabetes mellitus
Cohort
Smoking cessation
Female
business
Body mass index
Cohort study
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....ae7b9040f7471bdeaff452ccb8139df7