Back to Search
Start Over
A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants
- Source :
- Frontiers in Neurology, Frontiers in Neurology, Frontiers, 2021, 11, ⟨10.3389/fneur.2020.571657⟩, Frontiers in Neurology, Vol 11 (2021), Frontiers in Neurology, 2021, 11, ⟨10.3389/fneur.2020.571657⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Background: Primary progressive aphasias (PPA) have been investigated by clinical, therapeutic, and fundamental research but examiner-consistent language tests for reliable reproducible diagnosis and follow-up are lacking.Methods: We developed and evaluated a rapid language test for PPA (“PARIS”) assessing its inter-examiner consistency, its power to detect and classify PPA, and its capacity to identify language decline after a follow-up of 9 months. To explore the reliability and specificity/sensitivity of the test it was applied to PPA patients (N = 36), typical amnesic Alzheimer's disease (AD) patients (N = 24) and healthy controls (N = 35), while comparing it to two rapid examiner-consistent language tests used in stroke-induced aphasia (“LAST”, “ART”).Results: The application duration of the “PARIS” was ~10 min and its inter-rater consistency was of 88%. The three tests distinguished healthy controls from AD and PPA patients but only the “PARIS” reliably separated PPA from AD and allowed for classifying the two most frequent PPA variants: semantic and logopenic PPA. Compared to the “LAST” and “ART,” the “PARIS” also had the highest sensitivity for detecting language decline.Conclusions: The “PARIS” is an efficient, rapid, and highly examiner-consistent language test for the diagnosis, classification, and follow-up of frequent PPA variants. It might also be a valuable tool for providing end-points in future therapeutic trials on PPA and other neurodegenerative diseases affecting language processing.
- Subjects :
- medicine.medical_specialty
Test
Audiology
050105 experimental psychology
lcsh:RC346-429
Primary progressive aphasia
Primary progressive
Alzheiemer's disease
03 medical and health sciences
0302 clinical medicine
Language assessment
Aphasia
Diagnosis
Medicine
0501 psychology and cognitive sciences
Reliability (statistics)
lcsh:Neurology. Diseases of the nervous system
Original Research
Language
business.industry
05 social sciences
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
respiratory system
Alzheimer's disease
medicine.disease
Therapeutic trial
Neurology
Diagnosis Classification
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 16642295
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology, Frontiers in Neurology, Frontiers, 2021, 11, ⟨10.3389/fneur.2020.571657⟩, Frontiers in Neurology, Vol 11 (2021), Frontiers in Neurology, 2021, 11, ⟨10.3389/fneur.2020.571657⟩
- Accession number :
- edsair.doi.dedup.....aea3d4566a179338c315d861aae17898