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Coronary-artery bypass surgery in patients with left ventricular dysfunction
- Source :
- New England Journal of Medicine
- Publication Year :
- 2011
-
Abstract
- The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established.Between July 2002 and May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). The primary outcome was the rate of death from any cause. Major secondary outcomes included the rates of death from cardiovascular causes and of death from any cause or hospitalization for cardiovascular causes.The primary outcome occurred in 244 patients (41%) in the medical-therapy group and 218 (36%) in the CABG group (hazard ratio with CABG, 0.86; 95% confidence interval [CI], 0.72 to 1.04; P=0.12). A total of 201 patients (33%) in the medical-therapy group and 168 (28%) in the CABG group died from an adjudicated cardiovascular cause (hazard ratio with CABG, 0.81; 95% CI, 0.66 to 1.00; P=0.05). Death from any cause or hospitalization for cardiovascular causes occurred in 411 patients (68%) in the medical-therapy group and 351 (58%) in the CABG group (hazard ratio with CABG, 0.74; 95% CI, 0.64 to 0.85; P
- Subjects :
- Male
medicine.medical_specialty
Coronary Artery Disease
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
law.invention
Coronary artery disease
03 medical and health sciences
Coronary artery bypass surgery
Ventricular Dysfunction, Left
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Clinical endpoint
Humans
03.02. Klinikai orvostan
cardiovascular diseases
030212 general & internal medicine
Coronary Artery Bypass
Aged
Proportional Hazards Models
Heart Failure
Intention-to-treat analysis
Proportional hazards model
business.industry
Hazard ratio
Settore MED/23 - Chirurgia Cardiaca
General Medicine
Middle Aged
medicine.disease
Combined Modality Therapy
3. Good health
Surgery
Intention to Treat Analysis
Hospitalization
surgical procedures, operative
Cardiovascular Diseases
Heart failure
Cardiology
Female
business
Subjects
Details
- ISSN :
- 15334406
- Volume :
- 364
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- The New England journal of medicine
- Accession number :
- edsair.doi.dedup.....aebcec2c6e0a0ade0e9405d99b9ac387