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Chronic restraint stress exacerbates nociception and inflammatory response induced by bee venom in rats: the role of the P2X7 receptors
- Source :
- Neurological Research. 38:158-165
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Chronic restraint stress exacerbates pain and inflammation. The present study was designed to evaluate the effect of chronic restraint stress on inflammatory pain induced by subcutaneous injection of bee venom (BV).First, we investigated: (1) the effect of two-week restraint stress with daily 2 or 8 h on the baseline paw withdrawal mechanical threshold (PWMT), paw withdrawal thermal latency (PWTL) and paw circumference (PC); (2) the effect of chronic stress on the spontaneous paw-flinching reflex (SPFR), decrease in PWM, PWTL and increase in PC of the injected paw induced by BV.The results showed that (1) chronic restraint decreased significantly the PWMT and inhibited significantly the increase in PC, but had no effect on PWTL, compared with control group; (2) chronic restraint enhanced significantly BV-induced SPFR and inflammatory swelling of the injected paw. In a second series of experiments, the role of P2X7 receptor (P2X7R) in the enhancement of BV-induced inflammatory pain produced by chronic restraint stress was determined. Systemic pretreatment with P2X7R antagonist completely reversed the decrease in PWMT produced by chronic restraint, inhibited significantly the enhancement of BV-induced inflammatory pain produced by chronic restraint stress.Taken together, our data indicate that chronic restraint stress-enhanced nociception and inflammation in the BV pain model, possibly involving the P2X7R.
- Subjects :
- Male
Nociception
Pain Threshold
Restraint, Physical
0301 basic medicine
Time Factors
Inflammation
Pharmacology
Statistics, Nonparametric
Rats, Sprague-Dawley
03 medical and health sciences
Subcutaneous injection
0302 clinical medicine
Bee venom
Physical Stimulation
Purinergic P2 Receptor Antagonists
Animals
Medicine
Chronic stress
P2x7 receptor
Pain Measurement
Receptors, Purinergic P2
business.industry
Benzenesulfonates
Body Weight
General Medicine
Rats
Bee Venoms
Disease Models, Animal
030104 developmental biology
Neurology
Hyperalgesia
Anesthesia
Reflex
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17431328 and 01616412
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Neurological Research
- Accession number :
- edsair.doi.dedup.....aebef31a0263d1373b118c6acc4fd358