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Heavy Drinking Habits Are Associated with Worse In-Hospital Outcomes in Patients with Acute Coronary Syndrome: An Insight from the AMIS Plus Registry
- Source :
- Cardiology. 145:757-765
- Publication Year :
- 2020
- Publisher :
- S. Karger AG, 2020.
-
Abstract
- Background: The association between alcohol consumption and the occurrence of coronary heart disease is well described in the literature, while data regarding the impact of regular alcohol consumption on in-hospital outcomes in the setting of acute coronary syndrome (ACS) are lacking. We aimed to evaluate the impact of self-reported alcohol consumption on in-hospital outcomes in patients with ACS. Methods: Data derived from patients enrolled between 2007 and 2019 in the Acute Myocardial Infarction in Switzerland (AMIS) Plus registry were retrospectively analyzed. Patients were stratified based on alcohol drinking pattern. Primary outcome was all-cause in-hospital mortality, while secondary outcomes were set as incidence of major adverse cardiac and cerebrovascular events (MACCEs). Outcome comparisons according to quantity of daily alcohol intake were also performed. Results: Records concerning alcohol consumption were available in 25,707 patients; 5,298 of them (21%) fulfilled the criteria of regular alcohol consumption. Regular drinkers were predominantly male, younger, smokers, more comorbid and with a worse clinical presentation as compared with abstainers/occasional drinkers. Daily alcohol intake was reported in 4,059 (77%) of these patients (regular drinkers). Among them, 2,640 were light drinkers (≤2 drinks/day) and 1,419 heavy drinkers (>2 drinks/day). In-hospital mortality and MACCEs of heavy drinkers were significantly higher compared with those of light drinkers (5.4 vs. 3.3% and 7.0 vs. 4.4%, both p = 0.001). When tested together with Global Registry of Acute Coronary Events risk score parameters, heavy alcohol consumption was independently associated with in-hospital mortality (p = 0.004). Conclusions: Our results support that heavy alcohol consumption is an independent predictor of in-hospital mortality in patients presenting with ACS.
- Subjects :
- Male
medicine.medical_specialty
Acute coronary syndrome
Alcohol Drinking
Myocardial Infarction
610 Medicine & health
Alcohol
11171 Cardiocentro Ticino
2705 Cardiology and Cardiovascular Medicine
Habits
chemistry.chemical_compound
Risk Factors
Internal medicine
medicine
2736 Pharmacology (medical)
Humans
Pharmacology (medical)
In patient
Registries
Myocardial infarction
Acute Coronary Syndrome
Retrospective Studies
Framingham Risk Score
Heavy drinking
business.industry
Incidence (epidemiology)
10060 Epidemiology, Biostatistics and Prevention Institute (EBPI)
medicine.disease
Hospitals
Hospital outcomes
chemistry
Cardiology and Cardiovascular Medicine
business
Switzerland
Subjects
Details
- ISSN :
- 14219751 and 00086312
- Volume :
- 145
- Database :
- OpenAIRE
- Journal :
- Cardiology
- Accession number :
- edsair.doi.dedup.....aec1db294d7e468378dc961637ea80a2