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DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis
- Source :
- Journal of neuro-oncology. 109(2)
- Publication Year :
- 2012
-
Abstract
- Little is known about frequency, association with clinical characteristics, and prognostic impact of DNA copy number alterations (CNA) on survival in central primitive neuroectodermal tumors (CNS-PNET) and tumors of the pineal region. Searches of MEDLINE, Pubmed, and EMBASE--after the original description of comparative genomic hybridization in 1992 and July 2010--identified 15 case series of patients with CNS-PNET and tumors of the pineal region whose tumors were investigated for genome-wide CNA. One additional case study was identified from contact with experts. Individual patient data were extracted from publications or obtained from investigators, and CNAs were converted to a digitized format suitable for data mining and subgroup identification. Summary profiles for genomic imbalances were generated from case-specific data. Overall survival (OS) was estimated using the Kaplan-Meier method, and by univariable and multivariable Cox regression models. In their overall CNA profiles, low grade tumors of the pineal region clearly diverged from CNS-PNET and pineoblastoma. At a median follow-up of 89 months, 7-year OS rates of CNS-PNET, pineoblastoma, and low grade tumors of the pineal region were 22.9 ± 6, 0 ± 0, and 87.5 ± 12 %, respectively. Multivariable analysis revealed that histology (CNS-PNET), age (≤2.5 years), and possibly recurrent CNAs were associated with unfavorable OS. DNA copy number profiling suggests a close relationship between CNS-PNET and pineoblastoma. Low grade tumors of the pineal region differed from CNS-PNET and pineoblastoma. Due to their high biological and clinical variability, a coordinated prospective validation in future studies is necessary to establish robust risk factors.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Adolescent
DNA Copy Number Variations
Databases, Factual
International Cooperation
Brain tumor
Biology
Pineal Gland
chemistry.chemical_compound
Young Adult
Text mining
medicine
Humans
Neuroectodermal Tumors, Primitive
Child
Aged
Retrospective Studies
Pineoblastoma
Proportional hazards model
business.industry
Brain Neoplasms
Infant
Histology
Middle Aged
medicine.disease
Neurology
Oncology
chemistry
Meta-analysis
Child, Preschool
Multivariate Analysis
Female
Neurology (clinical)
business
Pinealoma
DNA
Comparative genomic hybridization
Subjects
Details
- ISSN :
- 15737373
- Volume :
- 109
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of neuro-oncology
- Accession number :
- edsair.doi.dedup.....aec577daa9463ae92d93469d2578245a