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Uterus-targeted liposomes for preterm labor management: studies in pregnant mice
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- Preterm labor caused by uterine contractions is a major contributor to neonatal morbidity and mortality. Treatment intended to reduce uterine contractions include tocolytic agents, such as indomethacin. Unfortunately, clinically used tocolytics are frequently inefficient and cross the placenta causing fetal side effects. Here we show for the first time in obstetrics the use of a targeted nanoparticle directed to the pregnant uterus and loaded with a tocolytic for reducing its placental passage and sustaining its efficacy. Nanoliposomes encapsulating indomethacin and decorated with clinically used oxytocin receptor antagonist were designed and evaluated in-vitro, ex-vivo and in-vivo. The proposed approach resulted in targeting uterine cells in-vitro, inhibiting uterine contractions ex-vivo, while doubling uterine drug concentration, decreasing fetal levels, and maintaining the preterm birth rate in vivo in a pregnant mouse model. This promising approach opens new horizons for drug development in obstetrics that could greatly impact preterm birth, which currently has no successful treatments.
- Subjects :
- Tocolytic agent
medicine.medical_specialty
Drug Compounding
Placenta
Indomethacin
Uterus
Gene Expression
Article
Mice
Uterine Contraction
03 medical and health sciences
Hormone Antagonists
Obstetric Labor, Premature
Vasotocin
0302 clinical medicine
Pregnancy
In vivo
medicine
Animals
Humans
Molecular Targeted Therapy
Fetus
030219 obstetrics & reproductive medicine
Multidisciplinary
Obstetrics
business.industry
medicine.disease
Oxytocin receptor
Nanostructures
3. Good health
Disease Models, Animal
Tocolytic Agents
medicine.anatomical_structure
Receptors, Oxytocin
Tocolytic
Liposomes
Premature Birth
Female
business
030217 neurology & neurosurgery
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....aecc12bca344e7eb9a7cd50560853b9f
- Full Text :
- https://doi.org/10.1038/srep34710