The effect of 1,3-butanediol and carbohydrate supplementation on running performance

Objectives Ingested ketogenic agents offer the potential to enhance endurance performance via the provision of an alternative exogenous, metabolically efficient, glycogen-sparing fuel (i.e. ketone bodies). This study aimed to assess the impact of combined carbohydrate and 1,3-butanediol (CHO-BD) supplementation on endurance performance, blood beta-hydroxybutyrate (βHB) concentration and glycolytic activity, in comparison to carbohydrate supplementation alone (CHO). Design Eleven male runners (age 38 ± 12 years, mass 67.3 ± 6.5 kg, height 174.5 ± 5.0 cm, V ˙ O 2 p e a k 64.2 ± 5.0 ml⋅kg−1⋅min−1) performed two experimental trials in a randomised crossover design. Methods Each trial consisted of 60 min of submaximal running, followed by a 5 km running time-trial (TT), and was performed following the ingestion of an energy matched ∼650 ml drink (CHO-BD or CHO). Results There was no difference in TT completion time between the trials (CHO: 1265 ± 93, CHO-BD: 1261 ± 96 s; p = 0.723). However, blood βHB concentration in the CHO-BD trial was at least double that of the CHO trial at all time points following supplementation (p Conclusions An energy matched CHO-BD supplementation drink raised βHB concentration and acutely lowered blood lactate concentration, without enhancing 5 km TT running performance.