Back to Search
Start Over
Maternal adipose tissue to early preeclampsia risk detection: Is the time to maternal ultrasound beyond fetal evaluation?
- Source :
- Journal of Obstetrics and Gynaecology Research. 47:2021-2030
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Introduction This study aims to determine the predictive capacity of isolated maternal periumbilical and epigastric fat measurements during pregnancy to hypertensive outcomes. Methods A cohort study was conducted with pregnant women in any trimester and followed until delivery to identify the outcomes of interest, preeclampsia (PE) and gestational hypertension (GH). The predictive capacity of fourth quartile measurements was compared with the first three quartiles of maternal subcutaneous and visceral adipose tissue from the periumbilical site (periumbilical m-SAT and m-VAT) (n = 155) and maternal adipose tissue from the epigastric site (preperitoneal m-SAT and m-VAT) (n = 261). The predictive ability of prepregnant body mass index (BMI) above 30 kg/m2 for PE and GH was also assessed. Results Fourth quartiles for the periumbilical ultrasound measurements were m-VAT 52.7 mm and m-SAT 21.7 mm. Preperitoneal site presents fourth quartiles m-VAT 15.2 mm and m-SAT 18.6 mm. Both m-VAT and m-SAT maternal periumbilical and preperitoneal sites are unable to predict PE, with the utmost sensitivity attributed to the periumbilical site m-SAT at 54%. The best PE predictor odds ratio (OR) found was the prepregnant BMI consistent with obesity, with an OR of 3.2 (95% CI 1.1-9.4), whereas the best OR to GH predictor was preperitoneal m-SAT with 8.9 (95% CI 2.3-34.6). Conclusion PE pathogenic mechanisms related to maternal abdominal adipose tissue include differences in molecular, cytological, and tissue levels not detected by ultrasound in a quantified gray scale assessment. Periumbilical or epigastric m-VAT use is not able to predict PE during pregnancy.
- Subjects :
- Gestational hypertension
medicine.medical_specialty
Subcutaneous Fat
Adipose tissue
Intra-Abdominal Fat
Body Mass Index
Preeclampsia
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Humans
Medicine
Fetus
030219 obstetrics & reproductive medicine
business.industry
Obstetrics
Obstetrics and Gynecology
Odds ratio
medicine.disease
Adipose Tissue
Quartile
030220 oncology & carcinogenesis
Female
business
Body mass index
Subjects
Details
- ISSN :
- 14470756 and 13418076
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Journal of Obstetrics and Gynaecology Research
- Accession number :
- edsair.doi.dedup.....af13c646da83b5b0aee84c6d0e603963