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Outcome of Critically Ill COVID-19 Patients According to the Setting of Corticosteroid Initiation—A Retrospective Observational Cohort Study

Authors :
Sebastian Voicu
Thomas Lacoste-Palasset
Isabelle Malissin
Shana Bekhit
Eléonore Cauchois
Sirine Dahmani
Melkir Saib
Caroline Grant
Giulia Naim
Aymen M’Rad
Adrien Pepin-Lehaleur
Jean-Michel Ekhérian
Nicolas Deye
Bruno Mégarbane
Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144))
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
Mégarbane, Bruno
Source :
Journal of Personalized Medicine, Journal of Personalized Medicine, 2021, 11 (12), pp.1359. ⟨10.3390/jpm11121359⟩, Journal of Personalized Medicine; Volume 11; Issue 12; Pages: 1359, Journal of Personalized Medicine, Vol 11, Iss 1359, p 1359 (2021)
Publication Year :
2021
Publisher :
HAL CCSD, 2021.

Abstract

(1) Background: Corticosteroids lower 28-day all-cause mortality in critically ill COVID-19 patients. However, the outcome of COVID-19 patients referred to the intensive care unit (ICU) for respiratory deterioration despite corticosteroids initiated during hospitalization before ICU admission has been poorly investigated. Our objective was to determine survival according to corticosteroid initiation setting. (2) Methods: We conducted a cohort study including all successive critically ill COVID-19 patients treated with corticosteroids and managed in our ICU. We compared survival, whether corticosteroids were initiated before (Cb-group) or after ICU admission (Ca-group), using a propensity score matching. (3) Results: Overall, 228 patients (67 years (56–74); 168M/60F; invasive mechanical ventilation on admission, 17%) were included with 63 patients in the Cb-group and 165 patients in the Ca-group. Survival to hospital discharge was 43% versus 69%, respectively (p = 0.001). In a multivariable analysis, factors associated with death were age (odds ratio, 1.07; 95%-confidence interval, (1.04–1.11); p < 0.0001), the sequential organ failure assessment (SOFA) score on ICU admission (1.30 (1.14–1.50); p = 0.0001) and corticosteroid initiation before ICU admission (2.64 (1.30–5.43); p = 0.007). No significant differences in outcome related to corticosteroid regimen were found. (4) Conclusions: Critically ill COVID-19 patients transferred to the ICU with deterioration despite corticosteroids initiated before admission have a less favorable outcome than patients receiving corticosteroids initiated after ICU admission.

Details

Language :
English
ISSN :
20754426
Database :
OpenAIRE
Journal :
Journal of Personalized Medicine, Journal of Personalized Medicine, 2021, 11 (12), pp.1359. ⟨10.3390/jpm11121359⟩, Journal of Personalized Medicine; Volume 11; Issue 12; Pages: 1359, Journal of Personalized Medicine, Vol 11, Iss 1359, p 1359 (2021)
Accession number :
edsair.doi.dedup.....af2169321b9c8927a81d90ac2f354689
Full Text :
https://doi.org/10.3390/jpm11121359⟩