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Risk of multiple sclerosis after head injury: record linkage study
Risk of multiple sclerosis after head injury: record linkage study
- Source :
- Journal of neurology, neurosurgery, and psychiatry. 77(3)
- Publication Year :
- 2006
-
Abstract
- Background: The possibility that head injury may influence the development of multiple sclerosis (MS) has been studied inconclusively in the past. Objective: To determine whether head injury is associated with an increased risk of MS. Method: Analysis of database of linked hospital and death records, comparing the occurrence of MS in a cohort of people admitted to hospital with head injury and a reference cohort. Results: The rate ratio for MS after head injury, compared with the reference cohort, was 1.1 (95% confidence interval, 0.88 to 1.36). There was no significant increase in the risk of MS at either short or long time periods after head injury. Using length of hospital stay as a proxy for severity of injury, there was no significant increase in the rate ratio for MS after head injuries with hospital stays of less than two days (rate ratio = 1.1 (0.71 to 1.57)), two or more days (rate ratio = 1.0 (0.68 to 1.45)), or seven or more days (rate ratio = 1.3 (0.64 to 2.34)). Conclusions: The method used, record linkage, ensures that patients’ recollection of injury, or any tendency to attribute MS to injury, cannot have influenced the results. Injuries to the head were not associated with either the aetiological initiation or the clinical precipitation of onset of multiple sclerosis.
- Subjects :
- Adult
Male
Risk
Paper
medicine.medical_specialty
Multiple Sclerosis
Adolescent
Rate ratio
Head trauma
Cohort Studies
Internal medicine
medicine
Craniocerebral Trauma
Humans
Risk factor
Child
Aged
business.industry
Head injury
Infant
Middle Aged
medicine.disease
Confidence interval
United Kingdom
Surgery
Causality
Psychiatry and Mental health
Child, Preschool
Cohort
Female
Neurology (clinical)
Medical Record Linkage
business
Record linkage
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 1468330X and 00223050
- Volume :
- 77
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Accession number :
- edsair.doi.dedup.....af2d7bf0b53b025b793103111b618f99