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Administration of Miltefosine and Meglumine Antimoniate in Healthy Dogs: Clinicopathological Evaluation of the Impact on the Kidneys
- Source :
- Toxicologic Pathology. 37:770-775
- Publication Year :
- 2009
- Publisher :
- SAGE Publications, 2009.
-
Abstract
- In canine leishmaniosis (CanL), kidneys are affected in virtually all dogs. Treatment of CanL is limited in Europe to meglumine antimoniate and miltefosine. This study evaluated the pharmacological, toxicological, and pathological effects of both drugs in healthy beagle dogs. Four male and four female dogs were divided into two groups. The animals in Group 1 were administered an oral solution of 2% of miltefosine at 2 mg/kg b.w. once a day, for twenty-eight days. The animals in Group 2 were administered a preparation of meglumine antimoniate at 100 mg/kg b.w. subcutaneously once a day for twenty-eight days. After treatment, all dogs were followed-up for a further twenty-eight days. Dogs were observed daily and clinically examined ten times throughout the study. On days -1 and 55 a renal biopsy was performed on all dogs and analyzed by light microscopy, immunofluorescence, and electron microscopy. All the examinations failed to demonstrate any lesions in the miltefosine-treated dogs. Conversely, all the meglumine antimoniate–treated dogs demonstrated severe tubular damage, characterized by tubular cell necrosis and apoptosis. In conclusion, although no clinical signs of renal disease were evident, the use of meglumine antimoniate in the pharmacological treatment approach of CanL-affected dogs should be carefully considered.
- Subjects :
- Male
medicine.medical_specialty
Phosphorylcholine
Meglumine antimoniate
Urinary system
Antiprotozoal Agents
Fluorescent Antibody Technique
Pharmacology
Kidney
Toxicology
Beagle
Gastroenterology
Pathology and Forensic Medicine
Random Allocation
Dogs
Meglumine
Internal medicine
Toxicity Tests
Organometallic Compounds
medicine
Animals
Leishmaniasis
Molecular Biology
Miltefosine
Meglumine Antimoniate
medicine.diagnostic_test
Histocytochemistry
business.industry
Body Weight
Cell Biology
Microscopy, Electron
Kidney Tubules
medicine.anatomical_structure
Pharmacodynamics
Female
Kidney Diseases
Renal biopsy
business
medicine.drug
Subjects
Details
- ISSN :
- 15331601 and 01926233
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Toxicologic Pathology
- Accession number :
- edsair.doi.dedup.....af2debb4b414a5f9b40634621411af0e
- Full Text :
- https://doi.org/10.1177/0192623309344088