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Association between Low Estimated Glomerular Filtration Rate and Risk of Cerebral Small-Vessel Diseases: A Meta-Analysis
- Source :
- Journal of Stroke and Cerebrovascular Diseases. 25:710-716
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs. Methods Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented. Results Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration. Conclusions This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimated glomerular filtration was most strongly associated with SCI (OR = 2.71) among subtypes of CSVDs.
- Subjects :
- medicine.medical_specialty
Pathology
Databases, Factual
Renal function
Disease
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Odds Ratio
medicine
Humans
Renal Insufficiency, Chronic
Cerebral infarction
business.industry
Rehabilitation
Odds ratio
medicine.disease
Confidence interval
Cerebral Small Vessel Diseases
Meta-analysis
Surgery
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 10523057
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Stroke and Cerebrovascular Diseases
- Accession number :
- edsair.doi.dedup.....af46edb8b6b18aa3e3490b0b4507c2fe