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Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death
- Source :
- European Journal of Pharmacology. 546:36-39
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases.
- Subjects :
- MAP Kinase Signaling System
Tyrphostins
medicine.disease_cause
p38 Mitogen-Activated Protein Kinases
Shiga Toxin
Chlorocebus aethiops
medicine
Animals
Phosphorylation
Protein kinase A
Protein Kinase Inhibitors
Vero Cells
Pharmacology
Cell Death
biology
Toxin
Shiga toxin
Molecular biology
Mitogen-activated protein kinase
biology.protein
Vero cell
sense organs
Tyrosine kinase
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 546
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....af5903b0acd815a9255026b4423a4be3
- Full Text :
- https://doi.org/10.1016/j.ejphar.2006.07.014