Back to Search Start Over

Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death

Authors :
Hiroko Sonoda
Katsuaki Ito
Shinji Yamasaki
Atsuko Horie
Mariko Shimono
Sayaka Oshikawa
Masahiro Ikeda
Yasuhiro Gunji
Source :
European Journal of Pharmacology. 546:36-39
Publication Year :
2006
Publisher :
Elsevier BV, 2006.

Abstract

The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases.

Details

ISSN :
00142999
Volume :
546
Database :
OpenAIRE
Journal :
European Journal of Pharmacology
Accession number :
edsair.doi.dedup.....af5903b0acd815a9255026b4423a4be3
Full Text :
https://doi.org/10.1016/j.ejphar.2006.07.014