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Immunological Changes Induced in Peach Allergy Patients with Systemic Reactions by Pru p 3 Sublingual Immunotherapy
- Source :
- Molecular nutritionfood research. 62(3)
- Publication Year :
- 2017
-
Abstract
- cope Sublingual immunotherapy using peach extract enriched in Pru p 3 (Pru p 3-enriched-SLIT) brings a new perspective to treating patients with allergy to lipid transfer proteins. We evaluated the immunological changes induced by Pru p 3-enriched-SLIT during one year. Methods and results Three groups were included: peach allergic patients who received Pru p 3-enriched-SLIT, peach allergic untreated patients and controls. Peripheral blood mononuclear cells were obtained before treatment and different time-points. Monocyte-derived dendritic cells (moDCs) maturation and lymphocyte proliferation were assessed by flow cytometry. Data showed a significant reduction of moDCs maturation status during one year of treatment and an increase in PD-L1. Moreover, we observed a significant decrease of the Pru p 3-specific proliferation of effector cells and an increase in Treg cells with higher PD-L1 expression and IL-10 production. These were observed in patients treated only. Conclusion Successful Pru p 3-enriched-SLIT is linked to an important immunosuppression of allergen-specific effector T cells maybe the increase of allergen-specific Treg cells. These cellular changes are orchestrated by the activity of moDCs promoting the expression PD-L1 that will participate in the regulatory response. These changes may serve as biomarkers during SLIT alongside other features such as IgE/IgG4 ratio. This article is protected by copyright. All rights reserved
- Subjects :
- 0301 basic medicine
Adult
Male
Allergy
Adolescent
Maximum Tolerated Dose
medicine.medical_treatment
Lymphocyte proliferation
Immunoglobulin E
Peripheral blood mononuclear cell
B7-H1 Antigen
Flow cytometry
03 medical and health sciences
Double-Blind Method
Food allergy
T-Lymphocyte Subsets
medicine
Humans
Plant Proteins
Prunus persica
Sublingual Immunotherapy
biology
medicine.diagnostic_test
business.industry
Immunosuppression
Dendritic Cells
Antigens, Plant
medicine.disease
030104 developmental biology
Treatment Outcome
Immunoglobulin G
Immunology
biology.protein
Female
business
Plant lipid transfer proteins
Food Hypersensitivity
Food Science
Biotechnology
Subjects
Details
- ISSN :
- 16134133
- Volume :
- 62
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Molecular nutritionfood research
- Accession number :
- edsair.doi.dedup.....af6888a340c4dc4ab5e037464512297d