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260 Impact of ‘atherosclerotic pabulum’ on in hospital mortality for SARS-CoV-2 infection. Is calcium score alone enough to identify at risk patients?

Authors :
Carlo Maria Dellino
Giulio Cabrelle
Marco Previtero
Saverio Continisio
Carolina Montonati
Martina Perazzolo Marra
Giorgio De Conti
Raffaella Motta
Sabino Iliceto
Valeria Pergola
Source :
European Heart Journal Supplements : Journal of the European Society of Cardiology
Publication Year :
2021
Publisher :
Oxford University Press, 2021.

Abstract

Although the primary cause of death in COVID-19 infection is respiratory failure, there are evidences that cardiac manifestations may contribute to overall mortality and can even be the primary cause of death. More importantly, it is recognized that COVID-19 is associated with a high incidence of thrombotic complications. Two-hundred-eighty-four patients with proven SARS-CoV-2 infection who had a non-contrast Chest CT at our facility were analysed for coronary calcium score. Clinical and radiological data were retrieved. Patients with coronary calcium had higher inflammatory burden at admission (d-dimer, CRP, Procalcitonin) and higher Troponin at admission and at zenith. While there was no correlation with presence of consolidation and ground glass opacities, patients with coronary calcium had higher incidence of bilateral infiltration and higher in-hospital mortality. Peak troponin was associated with higher mortality, intensive care unit admission and mechanical ventilation in both univariable at multivariate analysis. Calcium score has demonstrated to be a good prognostic indicator for in-hospital mortality in patients with SARS-CoV-2 infection. Patients with higher atherosclerotic burden are at higher risk of fatality and complications. Our findings could have significant clinical implications in selecting at risk patients for allocation of resources especially in those with ‘atherosclerotic pabulum’, where inflammation activated by SARS-CoV-2 may play a role in fatal and non-fatal events.

Details

Language :
English
ISSN :
15542815 and 1520765X
Volume :
23
Database :
OpenAIRE
Journal :
European Heart Journal Supplements : Journal of the European Society of Cardiology
Accession number :
edsair.doi.dedup.....af6a1e66ae57abef224829935f04397d