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Coexistence of SOS-Dependent and SOS-Independent Regulation of DNA Repair Genes in Radiation-Resistant
- Source :
- Cells, Cells, 2021, 10 (4), pp.924. ⟨10.3390/cells10040924⟩, Cells, MDPI, 2021, 10 (4), pp.924. ⟨10.3390/cells10040924⟩, Cells, Vol 10, Iss 924, p 924 (2021)
- Publication Year :
- 2021
-
Abstract
- Deinococcus bacteria are extremely resistant to radiation and able to repair a shattered genome in an essentially error-free manner after exposure to high doses of radiation or prolonged desiccation. An efficient, SOS-independent response mechanism to induce various DNA repair genes such as recA is essential for radiation resistance. This pathway, called radiation/desiccation response, is controlled by metallopeptidase IrrE and repressor DdrO that are highly conserved in Deinococcus. Among various Deinococcus species, Deinococcus radiodurans has been studied most extensively. Its genome encodes classical DNA repair proteins for error-free repair but no error-prone translesion DNA polymerases, which may suggest that absence of mutagenic lesion bypass is crucial for error-free repair of massive DNA damage. However, many other radiation-resistant Deinococcus species do possess translesion polymerases, and radiation-induced mutagenesis has been demonstrated. At least dozens of Deinococcus species contain a mutagenesis cassette, and some even two cassettes, encoding error-prone translesion polymerase DnaE2 and two other proteins, ImuY and ImuB-C, that are probable accessory factors required for DnaE2 activity. Expression of this mutagenesis cassette is under control of the SOS regulators RecA and LexA. In this paper, we review both the RecA/LexA-controlled mutagenesis and the IrrE/DdrO-controlled radiation/desiccation response in Deinococcus.
- Subjects :
- 0301 basic medicine
SOS response
translesion polymerase
SOS-independent
metallopeptidase IrrE
DNA Repair
DNA repair
DNA damage
DNA polymerase
QH301-705.5
DnaE2
[SDV]Life Sciences [q-bio]
030106 microbiology
repressor DdrO
Review
Deinococcus
Radiation Tolerance
03 medical and health sciences
SOS mutagenesis
A Deinococcus
Biology (General)
SOS Response, Genetics
radiation resistance
biology
Mutagenesis
Deinococcus radiodurans
General Medicine
Gene Expression Regulation, Bacterial
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Cell biology
030104 developmental biology
biology.protein
bacteria
Repressor lexA
Subjects
Details
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....af73a2b6dfd73f48940d20eed04a40f9
- Full Text :
- https://doi.org/10.3390/cells10040924⟩