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Prevalence of In Vitro Resistance to Eleven Standard or New Antimalarial Drugs among Plasmodium falciparum Isolates from Pointe-Noire, Republic of the Congo
- Source :
- Journal of Clinical Microbiology. 44:2404-2408
- Publication Year :
- 2006
- Publisher :
- American Society for Microbiology, 2006.
-
Abstract
- We determined the level of in vitro resistance of Plasmodium falciparum parasites to standard antimalarial drugs, such as chloroquine, quinine, amodiaquine, halofantrine, mefloquine, cycloguanil, and pyrimethamine, and to new compounds, such as dihydroartemisinin, doxycycline, atovaquone, and lumefantrine. The in vitro resistance to chloroquine reached 75.5%. Twenty-eight percent of the isolates were intermediate or had reduced susceptibility to quinine. Seventy-six percent and 96% of the tested isolates showed in vitro resistance or intermediate susceptibilities to cycloguanil and pyrimethamine, respectively. Only 2% of the parasites demonstrated in vitro resistance to monodesethylamodiaquine. No resistance was shown with halofantrine, lumefantrine, dihydroartemisinin, or atovaquone. Halofantrine, mefloquine, and lumefantrine demonstrated high correlation. No cross-resistance was identified between responses to monodesethyl-amodiaquine, dihydroartemisinin, atovaquone, and cycloguanil. Since the level of chloroquine resistance in vitro exceed an unacceptable upper limit, high rates of in vitro resistance to pyrimethamine and cycloguanil and diminution of the susceptibility to quinine, antimalarial drugs used in combination, such as amodiaquine, artemisinin derivatives, mefloquine, lumefantrine, or atovaquone, seem to be appropriate alternatives for the first line of treatment of acute, uncomplicated P. falciparum malaria.
- Subjects :
- Microbiology (medical)
Cycloguanil
Adolescent
medicine.medical_treatment
Plasmodium falciparum
Statistics as Topic
Drug Resistance
Dihydroartemisinin
Amodiaquine
Pharmacology
Lumefantrine
Antimalarials
chemistry.chemical_compound
Parasitic Sensitivity Tests
Halofantrine
parasitic diseases
medicine
Animals
Humans
Malaria, Falciparum
Artemisinin
Child
Mefloquine
business.industry
Infant
Congo
chemistry
Child, Preschool
Parasitology
business
Atovaquone
medicine.drug
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....afb6716d3bea2147fd5829b7ae66cf7f