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Single stranded DNA as an immunocytochemical marker for apoptotic change of ischemia in the gerbil hippocampus
- Source :
- Neuroscience Letters. 240:69-72
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- The light and electron microscopic localizations of single stranded DNA (SSD) protein, a marker of apoptosis and programmed cell death, in the gerbil hippocampus were examined by immunocytochemistry after transient brain ischemia. SSD-immunoreactive (IR) cells appeared from post-operative day 1 (PO 1) to PO 7 after 5- or 10-min ischemia. Immunoreaction was recognized in the nucleus of the CA1 pyramidal neurons without remarkable morphological changes on PO 1. These findings suggest that SSD degradation can occur during delayed neuronal death in the CA1, preceding the appearance of double strand breaks, one of the characteristic features of apoptosis.
- Subjects :
- Male
Programmed cell death
Pathology
medicine.medical_specialty
Immunocytochemistry
Ischemia
DNA, Single-Stranded
Hippocampus
Apoptosis
Biology
Gerbil
Brain Ischemia
Brain ischemia
medicine
Animals
General Neuroscience
medicine.disease
Immunohistochemistry
Molecular biology
DNA-Binding Proteins
medicine.anatomical_structure
Ribonucleoproteins
nervous system
Female
Gerbillinae
Nucleus
Biomarkers
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 240
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....afc681c32ca52efe75eddf7453b67b40