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Patient-reported neurocognitive symptoms influence instrumental activities of daily living in sickle cell disease
- Source :
- American journal of hematology, vol 96, iss 11, Am J Hematol
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Individuals with sickle cell disease (SCD) experience neurocognitive decline, low medication adherence, increased unemployment, and difficulty with instrumental activities of daily living (IADL). The relationship between self-perceived cognitive difficulties and IADLs, including employment, school enrollment, independence, engagement in leisure activities, and medication adherence is unknown. We hypothesized that self-reported difficulties across neurocognitive areas would predict lower IADL skills. Adolescent and adult participants of the multi-site Sickle Cell Disease Implementation Consortium (SCDIC) (n=2436) completed patient-reported outcome (PRO) measures of attention, executive functioning, processing speed, learning, and comprehension. Cognitive symptoms were analyzed as predictors in multivariable modeling. Outcome variables included 1) an IADL composite that consisted of employment, participation in school, reliance on others, and leisure pursuits, and 2) hydroxyurea adherence. Participants reported cognitive difficulty across areas of attention (55%), executive functioning (51%), processing speed (57%), and reading comprehension (65%). Executive dysfunction (p
- Subjects :
- Adult
Male
Activities of daily living
Adolescent
Functional skills
Immunology
Disease
Anemia, Sickle Cell
Cardiorespiratory Medicine and Haematology
Basic Behavioral and Social Science
Article
Medication Adherence
Young Adult
Rare Diseases
7.1 Individual care needs
Antisickling Agents
Clinical Research
Activities of Daily Living
Behavioral and Social Science
Medicine
Humans
Hydroxyurea
Cognitive Dysfunction
Pediatric
Sickle Cell Disease
business.industry
Pain Research
Neurosciences
Cognition
Anemia
Hematology
Middle Aged
Sickle Cell
Comprehension
Quality Education
Mental Health
Reading comprehension
Female
Management of diseases and conditions
Chronic Pain
business
Neurocognitive
Clinical psychology
Executive dysfunction
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- American journal of hematology, vol 96, iss 11, Am J Hematol
- Accession number :
- edsair.doi.dedup.....afc6b887ccd99e86e5a271ddf2d612ec