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Clinical Studies on the Treatment of Cancer Cachexia with Megestrol Acetate plus Thalidomide
- Source :
- Chemotherapy. 58:461-467
- Publication Year :
- 2012
- Publisher :
- S. Karger AG, 2012.
-
Abstract
- Background: The management of cancer-related anorexia/cachexia syndrome (CACS) is a great challenge in clinical practice. To date, practice guidelines for the prevention and treatment of CACS are lacking. The authors conducted a randomized study to confirm the effectiveness and safety of treatment of CACS utilizing megestrol acetate (MA) plus thalidomide. Methods: One hundred and two candidates with CACS were randomly assigned to two treatment groups (trial group and control group): the trial group received MA (160 mg po, bid) plus thalidomide (50 mg po, bid), while the control group received MA (160 mg po, bid) alone. Treatment duration was 8 weeks. Results: Analysis of the trial group demonstrated a significant increase from baseline in body weight (Conclusion: A combination regimen of MA and thalidomide is more effective than MA alone in the treatment of CACS.
- Subjects :
- Male
medicine.medical_specialty
Cachexia
Appetite Stimulants
Anorexia
Pharmacology
Gastroenterology
law.invention
Pharmacotherapy
Randomized controlled trial
Quality of life
law
Neoplasms
Internal medicine
Drug Discovery
medicine
Humans
Pharmacology (medical)
Fatigue
Aged
Hand Strength
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Megestrol Acetate
Body Weight
nutritional and metabolic diseases
General Medicine
Middle Aged
Prognosis
medicine.disease
Thalidomide
Regimen
Treatment Outcome
Infectious Diseases
Oncology
Megestrol acetate
Quality of Life
Drug Therapy, Combination
Female
medicine.symptom
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 14219794 and 00093157
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Chemotherapy
- Accession number :
- edsair.doi.dedup.....afcf0badba221b901a985b18139b0b04