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Targeted Iron-Oxide Nanoparticle for Photodynamic Therapy and Imaging of Head and Neck Cancer
- Source :
- ACS Nano
- Publication Year :
- 2014
- Publisher :
- American Chemical Society, 2014.
-
Abstract
- Photodynamic therapy (PDT) is a highly specific anticancer treatment modality for various cancers, particularly for recurrent cancers that no longer respond to conventional anticancer therapies. PDT has been under development for decades, but light-associated toxicity limits its clinical applications. To reduce the toxicity of PDT, we recently developed a targeted nanoparticle (NP) platform that combines a second-generation PDT drug, Pc 4, with a cancer targeting ligand, and iron oxide (IO) NPs. Carboxyl functionalized IO NPs were first conjugated with a fibronectin-mimetic peptide (Fmp), which binds integrin β1. Then the PDT drug Pc 4 was successfully encapsulated into the ligand-conjugated IO NPs to generate Fmp-IO-Pc 4. Our study indicated that both nontargeted IO-Pc 4 and targeted Fmp-IO-Pc 4 NPs accumulated in xenograft tumors with higher concentrations than nonformulated Pc 4. As expected, both IO-Pc 4 and Fmp-IO-Pc 4 reduced the size of HNSCC xenograft tumors more effectively than free Pc 4. Using a 10-fold lower dose of Pc 4 than that reported in the literature, the targeted Fmp-IO-Pc 4 NPs demonstrated significantly greater inhibition of tumor growth than nontargeted IO-Pc 4 NPs. These results suggest that the delivery of a PDT agent Pc 4 by IO NPs can enhance treatment efficacy and reduce PDT drug dose. The targeted IO-Pc 4 NPs have great potential to serve as both a magnetic resonance imaging (MRI) agent and PDT drug in the clinic.
- Subjects :
- Indoles
Peptidomimetic
medicine.medical_treatment
General Physics and Astronomy
Nanoparticle
Photodynamic therapy
02 engineering and technology
Ferric Compounds
Mice
0302 clinical medicine
Medicine
General Materials Science
Organosilicon Compounds
Molecular Targeted Therapy
media_common
Drug Carriers
Integrin beta1
General Engineering
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
3. Good health
Cell Transformation, Neoplastic
photodynamic therapy
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Toxicity
Carcinoma, Squamous Cell
0210 nano-technology
Drug carrier
therapeutics
Drug
integrin β1
Integrin β1
media_common.quotation_subject
Nanotechnology
Article
03 medical and health sciences
Animals
Humans
business.industry
Squamous Cell Carcinoma of Head and Neck
Head and neck cancer
medicine.disease
iron-oxide nanoparticle
Fibronectins
Photochemotherapy
Cancer research
Nanoparticles
head and neck cancer
Peptidomimetics
business
Fmp-IO-Pc 4
Subjects
Details
- Language :
- English
- ISSN :
- 1936086X and 19360851
- Volume :
- 8
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- ACS Nano
- Accession number :
- edsair.doi.dedup.....afd90c45257708b27f9ef929720028c8