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Peptidomimetics as Potent and Selective PTP1B Inhibitors
- Source :
- Medicinal Chemistry. 9:660-671
- Publication Year :
- 2013
- Publisher :
- Bentham Science Publishers Ltd., 2013.
-
Abstract
- A series of peptidomimetic containing bidentate pTyr mimetics (9a-w) are reported as potent and selective PTP1B inhibitors. Compounds (9p and 9q) showed excellent selectivity towards PTP1B over various PTPs, including TCPTP (in vitro), which confirms discovery of highly potent and selective PTP1B inhibitors.
- Subjects :
- Models, Molecular
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
Peptidomimetic
Dipeptides
Acetates
Amides
Combinatorial chemistry
In vitro
Substrate Specificity
Structure-Activity Relationship
Piperidines
Drug Discovery
Humans
Peptidomimetics
Enzyme Inhibitors
Selectivity
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15734064
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....afeba8e29bd88ae919d6e1580d319555
- Full Text :
- https://doi.org/10.2174/1573406411309050005