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AST-120, an Oral Carbon Absorbent, Protects against the Progression of Atherosclerosis in a Mouse Chronic Renal Failure Model by Preserving sFlt-1 Expression Levels
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Soluble Flt-1 (sFlt-1), an endogenous antagonist of the proatherogenic cytokine placental growth factor, is decreased in chronic kidney disease (CKD), leading to atherosclerotic progression. In this study, we investigated the effect of AST-120, an oral carbon adsorbent which can remove uremic toxins, on sFlt-1 expression levels and atherosclerosis progression. Atherosclerotic apolipoprotein E-deficient mice underwent a 5/6 nephrectomy (5/6 NR) or a sham operation (sham) at 8 weeks of age and were then treated or not with oral AST-120 for 12 weeks. sFlt-1 expression levels and the degree of atherosclerosis were assessed at 22 weeks of age in each of the four groups (sham; n = 7, 5/6 NR; n = 10, sham + AST-120: n = 8, 5/6 NR + AST-120; n = 8). The expression levels of sFlt-1 mRNA in the kidney were significantly lower in the 5/6 NR group than in the sham group, but AST-120 treatment prevented this decrease in sFlt-1 levels. Similarly, the atherosclerotic plaque area of the thoracoabdominal aorta was significantly larger in the 5/6 NR group than in the sham group, and AST-120 treatment prevented this increase in atherosclerosis. AST-120 could, therefore, be used as a therapeutic to treat atherosclerosis in patients with CKD.
- Subjects :
- Placental growth factor
medicine.medical_specialty
Apolipoprotein B
medicine.medical_treatment
030232 urology & nephrology
Administration, Oral
lcsh:Medicine
Endogeny
030204 cardiovascular system & hematology
Article
Calcification
Mice
03 medical and health sciences
0302 clinical medicine
Internal medicine
Human Umbilical Vein Endothelial Cells
medicine
Animals
Humans
RNA, Messenger
lcsh:Science
Kidney
Vascular Endothelial Growth Factor Receptor-1
Multidisciplinary
biology
business.industry
lcsh:R
Antagonist
Oxides
Atherosclerosis
medicine.disease
Carbon
Nephrectomy
Disease Models, Animal
medicine.anatomical_structure
Cytokine
Endocrinology
Gene Expression Regulation
Solubility
Disease Progression
biology.protein
Kidney Failure, Chronic
lcsh:Q
business
Kidney disease
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....aff8c916cfaab353e384184800afa795