CREBBP gene mutations are frequently detected in in situ follicular neoplasia

Authors :: Shan Chi Yu
Janine Schmidt
Reiner Siebert
Joan Enric Ramis-Zaldivar
Itziar Salaverria
Elaine S. Jaffe
Inga Müller
Julia Steinhilber
Irina Bonzheim
Andrea Haake
Mark Raffeld
Falko Fend
Leticia Quintanilla-Martinez
Source :: Blood. 132:2687-2690
Publication Year :: 2018
Publisher :: American Society of Hematology, 2018.
Abstract: TO THE EDITOR: Follicular lymphoma (FL) is characterized by the t(14;18)(q32;q21) chromosomal translocation,[1][1] found in ∼85% of manifest FL (mFL) cases. The t(14;18) is also present in early precursor lesions of FL and in a significant fraction of healthy individuals.[2][2],[3][3] This