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Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis
- Source :
- Frontiers in Neuroscience, Vol 15 (2021), Frontiers in Neuroscience
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Health Working Group and investigated these associations across 11 studies of 72,224 trauma-exposed individuals of European (n = 70,870) and African (n = 1,354) ancestry. Genetic contributions to blood pressure were modeled via polygenic scores (PGS) for systolic blood pressure (SBP) and diastolic blood pressure (DBP) that were derived from a prior trans-ethnic blood pressure genome-wide association study (GWAS). Results of trans-ethnic meta-analyses revealed significant main effects of the PGS on blood pressure levels [SBP: β = 2.83, standard error (SE) = 0.06, p < 1E-20; DBP: β = 1.32, SE = 0.04, p < 1E-20]. Significant main effects of PTSD symptoms were also detected for SBP and DBP in trans-ethnic meta-analyses, though there was significant heterogeneity in these results. When including data from the largest contributing study – United Kingdom Biobank – PTSD symptoms were negatively associated with SBP levels (β = −1.46, SE = 0.44, p = 9.8E-4) and positively associated with DBP levels (β = 0.70, SE = 0.26, p = 8.1E-3). However, when excluding the United Kingdom Biobank cohort in trans-ethnic meta-analyses, there was a nominally significant positive association between PTSD symptoms and SBP levels (β = 2.81, SE = 1.13, p = 0.01); no significant association was observed for DBP (β = 0.43, SE = 0.78, p = 0.58). Blood pressure PGS did not significantly moderate the associations between PTSD symptoms and blood pressure levels in meta-analyses. Additional research is needed to better understand the extent to which PTSD is associated with high blood pressure and how genetic as well as contextual factors may play a role in influencing cardiovascular risk.
- Subjects :
- 0301 basic medicine
Ethnic group
Neurosciences. Biological psychiatry. Neuropsychiatry
Genome-wide association study
Cardiovascular
03 medical and health sciences
0302 clinical medicine
Genetics
Medicine
Psychology
genetics
Risk factor
Original Research
Post-traumatic stress disorder (PTSD)
business.industry
General Neuroscience
Human Genome
Neurosciences
blood pressure
medicine.disease
trans-ethnic
Post-Traumatic Stress Disorder (PTSD)
meta-analysis
030104 developmental biology
Blood pressure
Standard error
Good Health and Well Being
Mental Health
posttraumatic stress disorder
Meta-analysis
Cohort
Cognitive Sciences
business
030217 neurology & neurosurgery
Neuroscience
RC321-571
Subjects
Details
- ISSN :
- 16624548
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neuroscience, Vol 15 (2021), Frontiers in Neuroscience
- Accession number :
- edsair.doi.dedup.....b015803a21cfe71216d19291b4677701