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Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients
- Source :
- Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE, Vol 8, Iss 5, p e64283 (2013), Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS ONE; Vol 8, Peters, L, Mocroft, A, Soriano, V, Rockstroh, J, Rauch, A, Karlsson, A, Knysz, B, Pradier, C, Zilmer, K, Lundgren, J D, Losso, M, Kundro, M, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, V M, Suetnov, O, Clumeck, N, De Wit, S, Delforge, M, Colebunders, R, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, J, Machala, L, Jilich, D, Sedlacek, D, Nielsen, J, Kronborg, G, Benfield, T, Larsen, M, Gerstoft, J, Katzenstein, T, Hansen, A B E, Skinhøj, P, Pedersen, C, Ostergaard, L, Smidt, J, Ristola, M, Katlama, C, Viard, J P, Girard, P M, Livrozet, J M, Vanhems, P, Dabis, F, Neau, D, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, H J, Staszewski, S, Bogner, J, Fätkenheuer, G, Kosmidis, J, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambatakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Maayan, S, Vella, S, Esposito, R, Mazeu, I, Mussini, C, Arici, C, Pristera, R, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Chirianni, A, Montesarchio, E, Gargiulo, M, Antonucci, G, Testa, A, D̀offizi, G, Vlassi, C, Zaccarelli, M, Antorini, A, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, d'Arminio Monforte, A, Rozentale, B, Zeltina, I, Chaplinskas, S, Staub, T, Hemmer, R, Reiss, P, Ormaasen, V, Maeland, A, Bruun, J, Gasiorowski, J, Horban, A, Bakowska, E, Grzeszczuk, A, Flisiak, R, Boron-Kaczmarska, A, Pynka, M, Parczewski, M, Beniowski, M, Mularska, E, Trocha, H, Jablonowska, E, Malolepsza, E, Wojcik, K, Antunes, F, Doroana, M, Caldeira, L, Mansinho, K, Maltez, F, Duiculescu, D, Rakhmanova, A, Zakharova, N, Buzunova, S, Jevtovic, D, Mokráš, M, Staneková, D, Tomazic, J, González-Lahoz, J, Labarga, P, Medrano, J, Moreno, S, Rodriguez, J M, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, J M, Miró, J M, Domingo, P, Gutierrez, M, Mateo, G, Sambeat, M A, Blaxhult, A, Flamholc, L, Ledergerber, B, Weber, R, Francioli, P, Cavassini, M, Hirschel, B, Boffi, E, Furrer, H, Battegay, M, Elzi, L, Kravchenko, E, Chentsova, N, Frolov, V, Kutsyna, G, Servitskiy, S, Krasnov, M, Barton, S, Johnson, A M, Mercey, D, Phillips, A, Johnson, M A, Murphy, M, Weber, J, Scullard, G, Fisher, M & Leen, C 2013, ' Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients ', PLOS ONE, vol. 8, no. 5, e64283 . https://doi.org/10.1371/journal.pone.0064283, PLoS ONE, PloS one, 8 (5, Peters, Lars; Mocroft, Amanda; Soriano, Vincent; Rockstroh, Jürgen; Rauch, Andri; Karlsson, Anders; Knysz, Brygida; Pradier, Christian; Zilmer, Kai; Lundgren, Jens D.; Blackard, Jason (2013). Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients. PLoS ONE, 8(5), e64283. Public Library of Science 10.1371/journal.pone.0064283
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Background:Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study.Methods:Patients included were positive for anti-HCV and/or HBsAg with at least one available plasma sample. The earliest collected plasma sample was tested for HA (normal range 0-75 ng/mL) and levels were associated with risk of LRE. Change in HA per year of follow-up was estimated after measuring HA levels in latest sample before the LRE for those experiencing this outcome (cases) and in a random selection of one sixth of the remaining patients (controls).Results:During a median of 8.2 years of follow-up, 84/1252 (6.7%) patients developed a LRE. Baseline median (IQR) HA in those without and with a LRE was 31.8 (17.2-62.6) and 221.6 ng/mL (74.9-611.3), respectively (p<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- Male
HBsAg
HIV opportunistic infections
Epidemiology
Gastroenterology and hepatology
Psychologie appliquée
Gastroenterology
0302 clinical medicine
middle aged
Medicine
blood/complications/mortality
hepatitis
Hyaluronic Acid
humans
lcsh:Science
0303 health sciences
Coinfection
adult
Incidence
risk assessment
Sciences bio-médicales et agricoles
3. Good health
prospective studies
blood/complications
hyaluronic acid
biological markers
male
disease progression
blood
hiv infections
prognosis
human
hepatic encephalopathy
young adult
female
roc curve
follow-up studies
incidence
viral
coinfection
Disease Progression
Infectious diseases
030211 gastroenterology & hepatology
Biologie
Human
medicine.medical_specialty
Hepatitis, Viral, Human
Prognosi
Acute Liver Failure
Risk Assessment
Follow-Up Studie
03 medical and health sciences
Liver diseases
Biochemistry, Genetics and Molecular Biology (all)
lcsh:R
Biomarker
medicine.disease
Prospective Studie
Agricultural and Biological Sciences (all)
Hepatic Encephalopathy
Immunology
lcsh:Q
Biomarkers
lcsh:Medicine
medicine.disease_cause
Hepatitis vírica
HIV Infection
Viral hepatitis
Prospective cohort study
Hepatic encephalopathy
Multidisciplinary
medicine.diagnostic_test
Incidence (epidemiology)
Medicine (all)
HIV diagnosis and management
Middle Aged
Hepatitis B
Hepatitis C
Infectious hepatitis
HIV clinical manifestations
Female
Research Article
Adult
Hepatitis C virus
610 Medicine & health
Viral diseases
Infectious Disease Epidemiology
Young Adult
Internal medicine
Biopsy
VIH (Virus)
ddc:610
030304 developmental biology
business.industry
HIV (Viruses)
HIV
ROC Curve
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE, Vol 8, Iss 5, p e64283 (2013), Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS ONE; Vol 8, Peters, L, Mocroft, A, Soriano, V, Rockstroh, J, Rauch, A, Karlsson, A, Knysz, B, Pradier, C, Zilmer, K, Lundgren, J D, Losso, M, Kundro, M, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, V M, Suetnov, O, Clumeck, N, De Wit, S, Delforge, M, Colebunders, R, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, J, Machala, L, Jilich, D, Sedlacek, D, Nielsen, J, Kronborg, G, Benfield, T, Larsen, M, Gerstoft, J, Katzenstein, T, Hansen, A B E, Skinhøj, P, Pedersen, C, Ostergaard, L, Smidt, J, Ristola, M, Katlama, C, Viard, J P, Girard, P M, Livrozet, J M, Vanhems, P, Dabis, F, Neau, D, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, H J, Staszewski, S, Bogner, J, Fätkenheuer, G, Kosmidis, J, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambatakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Maayan, S, Vella, S, Esposito, R, Mazeu, I, Mussini, C, Arici, C, Pristera, R, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Chirianni, A, Montesarchio, E, Gargiulo, M, Antonucci, G, Testa, A, D̀offizi, G, Vlassi, C, Zaccarelli, M, Antorini, A, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, d'Arminio Monforte, A, Rozentale, B, Zeltina, I, Chaplinskas, S, Staub, T, Hemmer, R, Reiss, P, Ormaasen, V, Maeland, A, Bruun, J, Gasiorowski, J, Horban, A, Bakowska, E, Grzeszczuk, A, Flisiak, R, Boron-Kaczmarska, A, Pynka, M, Parczewski, M, Beniowski, M, Mularska, E, Trocha, H, Jablonowska, E, Malolepsza, E, Wojcik, K, Antunes, F, Doroana, M, Caldeira, L, Mansinho, K, Maltez, F, Duiculescu, D, Rakhmanova, A, Zakharova, N, Buzunova, S, Jevtovic, D, Mokráš, M, Staneková, D, Tomazic, J, González-Lahoz, J, Labarga, P, Medrano, J, Moreno, S, Rodriguez, J M, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, J M, Miró, J M, Domingo, P, Gutierrez, M, Mateo, G, Sambeat, M A, Blaxhult, A, Flamholc, L, Ledergerber, B, Weber, R, Francioli, P, Cavassini, M, Hirschel, B, Boffi, E, Furrer, H, Battegay, M, Elzi, L, Kravchenko, E, Chentsova, N, Frolov, V, Kutsyna, G, Servitskiy, S, Krasnov, M, Barton, S, Johnson, A M, Mercey, D, Phillips, A, Johnson, M A, Murphy, M, Weber, J, Scullard, G, Fisher, M & Leen, C 2013, ' Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients ', PLOS ONE, vol. 8, no. 5, e64283 . https://doi.org/10.1371/journal.pone.0064283, PLoS ONE, PloS one, 8 (5, Peters, Lars; Mocroft, Amanda; Soriano, Vincent; Rockstroh, Jürgen; Rauch, Andri; Karlsson, Anders; Knysz, Brygida; Pradier, Christian; Zilmer, Kai; Lundgren, Jens D.; Blackard, Jason (2013). Hyaluronic Acid Levels Predict Risk of Hepatic Encephalopathy and Liver-Related Death in HIV/Viral Hepatitis Coinfected Patients. PLoS ONE, 8(5), e64283. Public Library of Science 10.1371/journal.pone.0064283 <http://dx.doi.org/10.1371/journal.pone.0064283>
- Accession number :
- edsair.doi.dedup.....b015dd1eb78651ef750e23e21f015b1f
- Full Text :
- https://doi.org/10.1371/journal.pone.0064283