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Intravenous versus oral vinorelbine plus capecitabine as second-line treatment in advanced breast cancer patients. A retrospective comparison of two consecutive phase II studies
- Source :
- Breast (Edinburgh, Scotland). 19(3)
- Publication Year :
- 2009
-
Abstract
- Vinorelbine (i.v.) plus capecitabine (oral) combination therapy is active in anthracycline/taxane pretreated patients with metastatic breast cancer. Availability of oral vinorelbine provides this combination in an all-oral formulation. Two consecutive phase II trials differing only in vinorelbine administration routes evaluated their respective activities and tolerabilities in this population. In the i.v. group (n = 38) disease control was 61% (37% PR, 24% SD), median TTP 6.8 months and median survival 11.3 months. In the oral group (n = 38) disease control was 77% (5.4% CR, 34% PR, 38% SD), median TTP 7 months and median survival 10 months. G3-G4 neutropenia was more common in the oral group (p < 0.05); G2-G3 anaemia [5] and G3 thrombocytopenia [1] were observed only in the oral group. Although the comparison between the two regimens was not randomized, the results observed in these two consecutive phase II studies may suggest that oral and iv vinorelbine, in combination with capecitabine, can achieve similar responses in patients with metastatic breast cancer refractory to anthra-taxane combinations.
- Subjects :
- Oncology
Adult
medicine.medical_specialty
Combination therapy
Anthracycline
Population
Administration, Oral
Antineoplastic Agents
Breast Neoplasms
Neutropenia
Vinorelbine
Vinblastine
Deoxycytidine
Capecitabine
Internal medicine
Medicine
Humans
education
Infusions, Intravenous
Aged
Retrospective Studies
education.field_of_study
Taxane
business.industry
General Medicine
Middle Aged
medicine.disease
Metastatic breast cancer
Combined Modality Therapy
Treatment Outcome
Surgery
Drug Therapy, Combination
Female
Fluorouracil
business
medicine.drug
Subjects
Details
- ISSN :
- 15323080
- Volume :
- 19
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Breast (Edinburgh, Scotland)
- Accession number :
- edsair.doi.dedup.....b02ad184f77ddf88aa305a4fe08226f3