Back to Search
Start Over
The Coronavirus SARS-Cov-2: the Characteristics of Structural Proteins, Contagiousness, and Possible Immune Collisions
- Source :
- Эпидемиология и вакцинопрофилактика, Vol 19, Iss 2, Pp 13-30 (2020)
- Publication Year :
- 2020
- Publisher :
- Numikom LLC, 2020.
-
Abstract
- Relevance. Coronavirus SARS-Cov-2 is a novel virus demonstrating the ability to be trans¬mitted from human-to-human, via respiratory droplets or close contact, and cause the severe acute respiratory syndrome (SARS). The role of its structural proteins in the SARS pathogenesis is unknown.Aim is to characterize the features of the SARS-Cov-2 structural proteins and their changes associated with acquiring other way of transmission and analyze the possibility of heterologous immunity emergence in its infection. Materials and method. For the computer analysis and alignment, the gene sequences of SARS-Cov-2 , SARS-CoV , MERS-CoV и bat CoV HKU3 reference strains were used from the Internet. From the primary structure of their genes it were translated their structural proteins: spike (S), envelope (E),membrane (M), and nucleocapsid (N). The genetic code of structural proteins was also defined. The search of homologous sequences in the SARS-Cov-2 S-protein, surface proteins of other viruses, and human proteins was made to find immune epitope continuum of protein relationships.Results. In the SARS-Cov-2 structural proteins amino acid sequences of M, E, and N-proteins are conservative. The S1 subunit of the S-protein contains some large insertions, significant changes of the amino acid content with the predominance of arginine and lysine which is typical for the surface glycoproteins in the viruses possessing high contagiousness. The S2 subunit is rather conservative and retain negative polarity. The S-protein exhibits the immune epitope relationships with many proteins of viruses and human which may be associated with immune collisions.Conclusion: The SARSCov-2 features are determined by marked changes of the S1 subunit structure in the S-protein which may be responsible for its contagiousness and many immune collisions aggravating infection process.
- Subjects :
- 0301 basic medicine
Epidemiology
Protein subunit
viruses
030106 microbiology
coronavirus
Biology
medicine.disease_cause
Epitope
03 medical and health sciences
Immune system
and immune collisions
medicine
BD143-237
genetic code contagiousness
Epistemology. Theory of knowledge
skin and connective tissue diseases
Gene
Coronavirus
Genetics
chemistry.chemical_classification
Public Health, Environmental and Occupational Health
Protein primary structure
structural proteins
biochemical phenomena, metabolism, and nutrition
Genetic code
Amino acid
030104 developmental biology
Infectious Diseases
chemistry
covid-19
Subjects
Details
- Language :
- Russian
- ISSN :
- 26190494 and 20733046
- Volume :
- 19
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Эпидемиология и вакцинопрофилактика
- Accession number :
- edsair.doi.dedup.....b03cacdd49e2b7509c6d0b9159ed3569