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CSF galanin and cognition after shunt surgery in normal pressure hydrocephalus
- Source :
- JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, ResearcherID, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname
- Publication Year :
- 2003
- Publisher :
- BMJ, 2003.
-
Abstract
- Background: “Normal” pressure hydrocephalus (NPH) is associated with injury to neurotransmitter and neuropeptide systems that recovers after surgery. This could be linked to changes in galanin, a neuropeptide with inhibitory effects on basal forebrain cognitive function. Objective: To examine changes in CSF galanin concentrations in patients with normal pressure hydrocephalus undergoing shunt surgery, and to investigate the relation between these changes and cognitive functioning. Methods: Eight patients underwent surgery for idiopathic normal pressure hydrocephalus. Lumbar CSF galanin determinations, cognitive status, and clinical status were quantified before operation and six months after. Cognition was assessed by an extensive battery of tests measuring attention, memory, speed of mental processing, visuospatial function, and frontal lobe function. Results: CSF galanin concentration decreased after surgery. This reduction correlated with improved clinical and cognitive functioning, specifically with attention and visuomotor speed, visuoconstructive and frontal functioning, and clinical status according to the NPH scale, including the sphincter and cognitive components. Conclusions: The cognitive and clinical improvement after shunt implantation correlated with CSF galanin levels, suggesting that the distribution or function of this agent involves cerebral structures that have some potential for recovery. In this study, galanin was related to several cognitive functions that may be associated with the fronto-subcortical deficits underlying cognitive dysfunction in normal pressure hydrocephalus.
- Subjects :
- Paper
Male
medicine.medical_specialty
Galanin
Central nervous system disease
Mental Processes
Cerebrospinal fluid
Memory
Normal pressure hydrocephalus
Internal medicine
medicine
Humans
Attention
Aged
Aged, 80 and over
Neurologic Examination
Cognitive disorder
Cognition
Middle Aged
medicine.disease
Cerebrospinal Fluid Shunts
Hydrocephalus, Normal Pressure
Frontal Lobe
Hydrocephalus
Psychiatry and Mental health
Endocrinology
nervous system
Frontal lobe
Cardiology
Female
Surgery
sense organs
Neurology (clinical)
Cognition Disorders
Psychology
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi.dedup.....b04c2d83f9d5174918b2910a5ec713d4