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MDSCs in infectious diseases: regulation, roles, and readjustment
- Source :
- Cancer Immunology, Immunotherapy, Cancer Immunology, Immunotherapy, Springer Verlag, 2019, 68 (4), pp.673-685. ⟨10.1007/s00262-018-2277-y⟩, Cancer immunology and immunotherapy, Cancer Immunology, Immunotherapy, 2019, 68 (4), pp.673-685. ⟨10.1007/s00262-018-2277-y⟩, Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- International audience; Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.
- Subjects :
- Cancer Research
Virus oncogènics
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
MDSC
Medizin
Disease
Mye-EUNITER
10263 Institute of Experimental Immunology
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
0302 clinical medicine
Immunology and Allergy
1306 Cancer Research
Molecular Targeted Therapy
Pathogen
Myeloid regulatory cells
Immunosuppression
Infeccions
3. Good health
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Oncology
Acute Disease
Host-Pathogen Interactions
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
2723 Immunology and Allergy
[SDV.IMM]Life Sciences [q-bio]/Immunology
2730 Oncology
Disease Susceptibility
Infection
Oncovirus
Immunology
Virulence
610 Medicine & health
Biology
Infections
Communicable Diseases
Immunomodulation
03 medical and health sciences
medicine
Animals
Humans
2403 Immunology
Immunosupressió
Myeloid-Derived Suppressor Cells
Oncogenic viruses
Multicellular organism
Chronic Disease
Myeloid cells
570 Life sciences
biology
Human medicine
Biomarkers
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 03407004 and 14320851
- Database :
- OpenAIRE
- Journal :
- Cancer Immunology, Immunotherapy, Cancer Immunology, Immunotherapy, Springer Verlag, 2019, 68 (4), pp.673-685. ⟨10.1007/s00262-018-2277-y⟩, Cancer immunology and immunotherapy, Cancer Immunology, Immunotherapy, 2019, 68 (4), pp.673-685. ⟨10.1007/s00262-018-2277-y⟩, Dipòsit Digital de la UB, Universidad de Barcelona
- Accession number :
- edsair.doi.dedup.....b04fd74599f78d8497987da32619ab82