Back to Search
Start Over
A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome
- Source :
- Nutrients; Volume 10; Issue 1; Pages: 6, Nutrients, Vol 10, Iss 1, p 6 (2017), Nutrients, Shokouh, P, Jeppesen, P B, Hermansen, K, Nørskov, N P, Laustsen, C, Jacques Hamilton-Dutoit, S, Qi, H, Stødkilde-Jørgensen, H & Gregersen, S 2018, ' A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome ', Nutrients, vol. 10, no. 1, 6 . https://doi.org/10.3390/nu10010006
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Since coffee may help to prevent the development of metabolic syndrome (MetS), we aimed to evaluate the short- and long-term effects of a coffee-based supplement on different features of diet-induced MetS. In this study, 24 Sprague Dawley rats were divided into control or nutraceuticals groups to receive a high-fat/high-fructose diet with or without a mixture of caffeic acid (30 mg/day), trigonelline (20 mg/day), and cafestol (1 mg/day) for 12 weeks. An additional 11 rats were assigned to an acute crossover study. In the chronic experiment, nutraceuticals did not alter body weight or glycemic control, but improved fed hyperinsulinemia (mean difference = 30.80 mU/L, p = 0.044) and homeostatic model assessment-insulin resistance (HOMA-IR) (mean difference = 15.29, p = 0.033), and plasma adiponectin levels (mean difference = -0.99 µg/mL, p = 0.048). The impact of nutraceuticals on post-prandial glycemia tended to be more pronounced after acute administration than at the end of the chronic study. Circulating (mean difference = 4.75 U/L, p = 0.014) and intrahepatocellular alanine transaminase activity was assessed by hyperpolarized-13C nuclear magnetic resonance NMR spectroscopy and found to be reduced by coffee nutraceuticals at endpoint. There was also a tendency towards lower liver triglyceride content and histological steatosis score in the intervention group. In conclusion, a mixture of coffee nutraceuticals improved insulin sensitivity and exhibited hepatoprotective effects in a rat model of MetS. Higher dosages with or without caffeine deserve to be studied in the future.
- Subjects :
- 0301 basic medicine
Blood Glucose
Time Factors
HIGH-FAT DIET
medicine.medical_treatment
Cafestol
Coffea
coffee
dietary supplements
metabolic syndrome X
non-alcoholic fatty liver disease
adiponectin
hyperpolarized magnetic resonance spectroscopy
Rats, Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Dietary Sucrose
ABSORPTION
Hyperinsulinemia
Insulin
RISK
PLASMA-GLUCOSE
Metabolic Syndrome
Nutrition and Dietetics
Dietary supplements
Lipids
nutrition
Biochemistry
Liver
Seeds
Cytokines
Diterpenes
Caffeine
lcsh:Nutrition. Foods and food supply
medicine.drug
medicine.medical_specialty
CHLOROGENIC ACID
030209 endocrinology & metabolism
lcsh:TX341-641
Diet, High-Fat
Article
03 medical and health sciences
Alkaloids
Caffeic Acids
Metabolic syndrome X
Trigonelline
Internal medicine
medicine
Animals
Carbon-13 Magnetic Resonance Spectroscopy
030109 nutrition & dietetics
Adiponectin
business.industry
CONSUMPTION
medicine.disease
MICE
Disease Models, Animal
Endocrinology
chemistry
DOSE-RESPONSE METAANALYSIS
Insulin Resistance
Steatosis
Metabolic syndrome
business
CAFFEIC ACID
RESISTANCE
Food Science
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nutrients; Volume 10; Issue 1; Pages: 6, Nutrients, Vol 10, Iss 1, p 6 (2017), Nutrients, Shokouh, P, Jeppesen, P B, Hermansen, K, Nørskov, N P, Laustsen, C, Jacques Hamilton-Dutoit, S, Qi, H, Stødkilde-Jørgensen, H & Gregersen, S 2018, ' A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome ', Nutrients, vol. 10, no. 1, 6 . https://doi.org/10.3390/nu10010006
- Accession number :
- edsair.doi.dedup.....b064087a8a20eab3b707b62d27559660