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Epigenetic Regulation of Dental Pulp Stem Cell Fate

Authors :
Xin Zhou
Yiran Peng
Dan Zhou
Mian Wan
Lu Gan
Xuedong Zhou
Liwei Zheng
Xin Xu
Yachuan Zhou
Yi Fan
Wei Du
Source :
Stem Cells International, Stem Cells International, Vol 2020 (2020)
Publication Year :
2020
Publisher :
Hindawi Limited, 2020.

Abstract

Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.

Details

ISSN :
16879678 and 1687966X
Volume :
2020
Database :
OpenAIRE
Journal :
Stem Cells International
Accession number :
edsair.doi.dedup.....b06b4e9521d6d3a3ba82a79a4e008c55
Full Text :
https://doi.org/10.1155/2020/8876265