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Epigenetic Regulation of Dental Pulp Stem Cell Fate
- Source :
- Stem Cells International, Stem Cells International, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.
- Subjects :
- 0301 basic medicine
biology
Cellular differentiation
Mesenchymal stem cell
Review Article
Cell Biology
Cell fate determination
RC31-1245
Regenerative medicine
Cell biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Histone
stomatognathic system
030220 oncology & carcinogenesis
Dental pulp stem cells
DNA methylation
biology.protein
Epigenetics
Internal medicine
Molecular Biology
Subjects
Details
- ISSN :
- 16879678 and 1687966X
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Stem Cells International
- Accession number :
- edsair.doi.dedup.....b06b4e9521d6d3a3ba82a79a4e008c55
- Full Text :
- https://doi.org/10.1155/2020/8876265