Back to Search Start Over

Emergence of BCR-ABL–specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment

Emergence of BCR-ABL–specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment

Authors :
Sabrina Basso
Monica Maccaferri
Roberto D'Amico
Monica Morselli
Chiara Quadrelli
Giuseppe Torelli
Daniela Vallerini
Patrizia Barozzi
Franco Locatelli
Francesco Volzone
Fabio Forghieri
Patrizia Comoli
Mario Luppi
Cinzia Del Giovane
Leonardo Potenza
Giovanni Riva
Eleonora Zanetti
Source :
Blood. 115:1512-1518
Publication Year :
2010
Publisher :
American Society of Hematology, 2010.

Abstract

Imatinib mesylate has been demonstrated to allow the emergence of T cells directed against chronic myeloid leukemia cells. A total of 10 Philadelphia chromosome–positive acute lymphoblastic leukemia patients receiving high-dose imatinib mesylate maintenance underwent long-term immunological monitoring (range, 2-65 months) of p190BCR-ABL–specific T cells in the bone marrow and peripheral blood. p190BCR-ABL–specific T lymphocytes were detected in all patients, more frequently in bone marrow than in peripheral blood samples (67% vs 25%, P < .01) and resulted significantly associated with lower minimal residual disease values (P < .001), whereas absent at leukemia relapse. Specific T cells were mainly effector memory CD8+ and CD4+ T cells, producing interferon-γ, tumor necrosis factor-α, and interleukin-2 (median percentage of positive cells: 3.34, 3.04, and 3.58, respectively). Cytotoxic subsets able to lyse BCR-ABL–positive leukemia blasts also were detectable. Whether these autologous p190BCR-ABL–specific T cells may be detectable under other tyrosine-kinase inhibitors, expanded ex vivo, and exploited for immunotherapy remains to be addressed.

Details

ISSN :
15280020 and 00064971
Volume :
115
Database :
OpenAIRE
Journal :
Blood
Accession number :
edsair.doi.dedup.....b06d42cf52de9834d992f7820fe38c53
Full Text :
https://doi.org/10.1182/blood-2009-06-230391