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Quantification of Cerebellar Crowding in Type I Chiari Malformation
- Source :
- Annals of Biomedical Engineering. 47:731-743
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- This study was focused on a semi-automated morphometric analysis of the cerebellum in the mid-sagittal plane as an alternative to tonsillar descent alone in the evaluation of Chiari malformation type 1 (CMI) patients. Morphometric analyses of posterior fossa structures were performed on mid-sagittal MRI images of 375 individuals (females, > 18 years, 235 CMI and 140 healthy controls). Twenty-six parameters including linear, angular and area measurements together with non-dimensional ratios were calculated. Eighteen parameters were found to be significantly different between CMI and control subjects. Smaller posterior cranial fossa (PCF) area in CMI subjects was attributed to a smaller PCF area anterior to the brainstem. The cerebellar area was found to be larger in CMI subjects as compared to controls (15.1%), even without inclusion of the tonsillar area below the foramen magnum (FM) (8.4%). The larger cerebellar area in CMI subjects was due to cranial–caudal elongation of the cerebellum, predominately below the fastigium. The cerebrospinal fluid spaces below the FM were smaller in CMI subjects as compared to controls. Overall, greater cerebellar crowding was identified in CMI subjects relative to healthy controls. These observations may improve our understanding of the pathophysiology of CMI in adult female patients.
- Subjects :
- Adult
Cerebellum
0206 medical engineering
Biomedical Engineering
chemical and pharmacologic phenomena
02 engineering and technology
complex mixtures
Young Adult
Cerebrospinal fluid
parasitic diseases
medicine
Humans
Chiari malformation
Foramen magnum
Crowding in
business.industry
Brain
Anatomy
Middle Aged
bacterial infections and mycoses
medicine.disease
020601 biomedical engineering
Pathophysiology
Arnold-Chiari Malformation
medicine.anatomical_structure
Posterior cranial fossa
Female
Brainstem
business
therapeutics
Subjects
Details
- ISSN :
- 15739686 and 00906964
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Annals of Biomedical Engineering
- Accession number :
- edsair.doi.dedup.....b07c55bd5b24252ecedc9d343a31679b