Back to Search
Start Over
A recent epidemiological cluster of acute hepatitis B genotype F1b infection in a restricted geographical area of Italy
- Source :
- Clinical Microbiology and Infection. 21:1124.e1-1124.e4
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- In this study, by phylogenetic analysis, we identified an epidemiological cluster involving eight individuals diagnosed with acute hepatitis B virus (HBV) infection related to unprotected sexual intercourse in a restricted area of central Italy (time period: 2011–2014). Notably, these patients (six of eight Italians) were infected by subgenotype F1b, which is not commonly found in western countries. Ultra-deep pyrosequencing confirmed a superimposable composition of HBV quasi-species in these patients. Despite the availability of effective vaccination, this study highlights the importance of not underestimating the risk of HBV infection, of continuing to set up surveillance programmes for HBV infection, and of investigating the pathogenetic potential of these atypical genotypes.
- Subjects :
- Adult
Male
Microbiology (medical)
Hepatitis B virus
medicine.medical_specialty
Unprotected Sexual Intercourse
Sexual transmission
genotype
medicine.disease_cause
Disease cluster
vaccine
Genotype
Epidemiology
HBV
Humans
Medicine
Phylogeny
epidemiological cluster
business.industry
High-Throughput Nucleotide Sequencing
Acute infection
Sequence Analysis, DNA
Sexually Transmitted Diseases, Viral
General Medicine
Middle Aged
Hepatitis B
Settore MED/07 - Microbiologia e Microbiologia Clinica
medicine.disease
Virology
Vaccination
Phylogeography
Infectious Diseases
Italy
DNA, Viral
Immunology
Female
business
Subjects
Details
- ISSN :
- 1198743X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Clinical Microbiology and Infection
- Accession number :
- edsair.doi.dedup.....b08d371a1dd9d19502ec8bc3cc5e55e5