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Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women
- Source :
- Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2008, 93 (11), pp.4315-22. ⟨10.1210/jc.2008-0814⟩, Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2008, 93 (11), pp.4315-22. 〈10.1210/jc.2008-0814〉, Journal of Clinical Endocrinology & Metabolism, 93(11), 4315-4322. Oxford University Press, Journal of Clinical Endocrinology and Metabolism, 2008, 93 (11), pp.4315-22. ⟨10.1210/jc.2008-0814⟩, Dadun. Depósito Académico Digital de la Universidad de Navarra, instname
- Publication Year :
- 2008
- Publisher :
- HAL CCSD, 2008.
-
Abstract
- Context: Hypoenergetic diets are used to reduce body fat mass and metabolic risk factors in obese subjects. The molecular changes in adipose tissue associated with weight loss and specifically related to the dietary composition are poorly understood. Objective: We investigated adipose tissue gene expression from human obese women according to energy deficit and, the fat and carbohydrate content of the diet. Design & setting: Obese subjects recruited among 8 European clinical centers followed 10 weeks of either a low fat (high carbohydrate) or a moderate fat (low carbohydrate) hypoenergetic diet. Subjects: Two sets of 47 women in each dietary arm were selected among 648 subjects matched for anthropometric and biological parameters. Main Outcome Measure: We measured adipose tissue gene expression changes in one set using a candidate gene approach. The other set was used to survey 24469 transcripts using DNA microarrays. Results were analyzed using dedicated statistical methods. Diet-sensitive regulations were confirmed on the other set of subjects. Results: The two diets induced similar weight loss and similar changes for most of the biological variables except for components of the blood lipid profile. A thousand genes were regulated by energy restriction. We validated an effect of the fat-to-carbohydrate ratio for five genes (FABP4, NR3C1, SIRT3, FNTA and GABARAPL2) with increased expression during the moderate fat diet. Conclusions: Energy restriction had a more pronounced impact on variations in human adipose tissue gene expression than macronutrient composition. The macronutrient-sensitive regulation of a subset of genes may influence adipose tissue function and metabolic response. AD - INSERM, U858, Laboratoire de Recherches sur les Obesites, Institut de Medecine Moleculaire de Rangueil, Toulouse; Universite Paul Sabatier, Institut Louis Bugnard IFR31, Toulouse; Centre Hospitalier Universitaire de Toulouse, France; Franco-Czech Laboratory for Clinical Research on Obesity, Prague, Czech Republic; INSERM, UMR -870; INRA U-1235; Faculte de Medecine Lyon-Sud universite de Lyon 1; Centre de Recherche en Nutrition Humaine, Hospices civils de Lyon; Lyon, France; Institut de Mathematiques de Toulouse UMR 5219, Universite Paul-Sabatier, Toulouse, France; Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Sports Medicine, Centre of Preventive Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic; Franco-Czech Laboratory for Clinical Research on Obesity, Prague, Czech Republic; Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain; Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands; Institute of Preventive Medicine, Centre for Health and Society, Copenhagen University Hospital, Copenhagen, Denmark; School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham Medical School, Nottingham, United Kingdom; INSERM, Nutriomique U872 (Team 7), 75004 Paris, France; Universites Pierre et Marie Curie-Paris6, UMR-S 872, Cordelier Research Center & Paris Descartes, 75006 Paris; and Assistance Publique/Hopitaux de Paris (AP-HP), Pitie Salpetriere Hospital, Nutrition and Endocrinology department, 75013 Paris, France.
- Subjects :
- Transcription, Genetic
Endocrinology, Diabetes and Metabolism
MESH: Energy Intake
Biochemistry
Body Mass Index
0302 clinical medicine
Endocrinology
Gene expression
MESH: Genetic Variation
MESH : Adaptor Proteins, Signal Transducing
Oligonucleotide Array Sequence Analysis
0303 health sciences
Addipose tissue
Reducing
MESH: Mitochondrial Proteins
[ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
3. Good health
MESH : Oligonucleotide Array Sequence Analysis
Adipose Tissue
Body Composition
MESH: Adipose Tissue
medicine.medical_specialty
Diet, Reducing
MESH : Body Composition
MESH : Adipose Tissue
MESH: Body Mass Index
MESH : Receptors, Glucocorticoid
03 medical and health sciences
MESH: Weight Loss
Genetic
Humans
MESH : Fatty Acid-Binding Proteins
MESH : Mitochondrial Proteins
MESH: Adaptor Proteins, Signal Transducing
MESH: Humans
MESH : Humans
Signal Transducing
Genetic Variation
MESH: Adult
Autophagy-Related Protein 8 Family
MESH: Body Composition
medicine.disease
Obesity
MESH : Energy Metabolism
MESH : Body Mass Index
Energy intake
Body mass index
MESH: Female
Candidate gene
MESH: Receptors, Glucocorticoid
Clinical Biochemistry
Adipose tissue
Blood lipids
Glucocorticoid
Weight loss
Sirtuin 3
Receptors
MESH : RNA
Sirtuins
MESH: Obesity
MESH : Female
Nutrición y dietética [Ciencias de la Salud]
MESH : Diet, Reducing
2. Zero hunger
MESH : Sirtuins
MESH: Diet, Reducing
Microfilament Proteins
MESH: Energy Metabolism
Adaptor Proteins
MESH : Adult
MESH: Sirtuins
MESH : Obesity
Female
medicine.symptom
Transcription
Adult
MESH : Microfilament Proteins
030209 endocrinology & metabolism
Context (language use)
Biology
Fatty Acid-Binding Proteins
MESH: Fatty Acid-Binding Proteins
Mitochondrial Proteins
MESH: Microfilament Proteins
Receptors, Glucocorticoid
MESH : Genetic Variation
MESH: RNA
Internal medicine
Weight Loss
medicine
030304 developmental biology
Adaptor Proteins, Signal Transducing
MESH: Transcription, Genetic
Biochemistry (medical)
MESH : Transcription, Genetic
MESH : Energy Intake
Diet
MESH: Oligonucleotide Array Sequence Analysis
RNA
MESH : Weight Loss
Energy Intake
Energy Metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021972X and 19457197
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2008, 93 (11), pp.4315-22. ⟨10.1210/jc.2008-0814⟩, Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2008, 93 (11), pp.4315-22. 〈10.1210/jc.2008-0814〉, Journal of Clinical Endocrinology & Metabolism, 93(11), 4315-4322. Oxford University Press, Journal of Clinical Endocrinology and Metabolism, 2008, 93 (11), pp.4315-22. ⟨10.1210/jc.2008-0814⟩, Dadun. Depósito Académico Digital de la Universidad de Navarra, instname
- Accession number :
- edsair.doi.dedup.....b0d0ede3300cf21b1e236a198dd356ce