Contrast medium-induced pulmonary vascular hyperpermeability is aggravated in a rat climacterium model

Tominaga K, Kataoka Y, Sendo T, et al. Contrast medium-induced pulmonary vascular hyperpermeability is aggravated in a rat climacterium model. Invest Radiol 2001;36:131-135.To test whether climacterium influences adverse pulmonary reactions to contrast media, the authors investigated the effect of ioxaglate on pulmonary vascular permeability in ovariectomized rats as a climacterium model.From 7 days after surgery, ovariectomized rats were treated with estradiol valerate or vehicle once per week for 3 weeks. At 28 days after surgery, ioxaglate, an ionic contrast medium, was intravenously injected at 1.5 mL/min in rats. Pulmonary vascular permeability was evaluated by measuring the amount of Evans blue dye in the lung tissue.Ioxaglate dose-dependently increased pulmonary vascular permeability in sham-operated and ovariectomized rats. Ovariectomized rats showed a 2.6-fold increased aggravation of vascular permeability by ioxaglate 4 g I/kg compared with sham-operated rats. Estradiol valerate (0.2-5.0 mg/kg) dose-dependently blocked ioxaglate-increased vascular permeability in ovariectomized rats.These findings suggest that climacterium is included, at least in part, in the risk factors for contrast-induced adverse pulmonary reactions, and this risk is lowered by estrogen replacement therapy.