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Genetic variations in MicroRNA genes and cancer risk
- Source :
- EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, Park, J H, Jeong, G H, Lee, K S, Lee, K H, Suh, J S, Eisenhut, M, van der Vliet, H J, Kronbichler, A, Stubbs, B, Solmi, M, Dragioti, E, Koyanagi, A, Shin, J I & Gamerith, G 2020, ' Genetic variations in MicroRNA genes and cancer risk : A field synopsis and meta-analysis ', European Journal of Clinical Investigation, vol. 50, no. 4, e13203 . https://doi.org/10.1111/eci.13203, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu
- Publication Year :
- 2020
-
Abstract
- Background: Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. Method: We searched PubMed and investigated the results of meta-analyses published through November 2018. We re-assessed the results based on false-positive report probability (FPRP) to test the noteworthiness of the associations. Results: Sixty-eight miRNA polymorphisms in 45 meta-analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP
- Subjects :
- Oncology
medicine.medical_specialty
Candidate gene
Clinical Biochemistry
Single-nucleotide polymorphism
030204 cardiovascular system & hematology
Biology
Polymorphism, Single Nucleotide
Biochemistry
03 medical and health sciences
0302 clinical medicine
Meta-Analysis as Topic
Neoplasms
Internal medicine
Genotype
Genetic variation
microRNA
medicine
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
FPRP, cancer, gene variant, meta-analysis, microRNA
Gene
Genetic Variation
Reproducibility of Results
General Medicine
Odds ratio
MicroRNAs
Meta-analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00142972
- Volume :
- 50
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....b0eb4c94ebdb0cb78444e28263d22a8e