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A Systematic Review of Longitudinal Studies Which Measure Alzheimer’s Disease Biomarkers
- Source :
- Journal of Alzheimer's Disease
- Publication Year :
- 2017
- Publisher :
- IOS Press, 2017.
-
Abstract
- Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease, with no effective treatment or cure. A gold standard therapy would be treatment to slow or halt disease progression; however, knowledge of causation in the early stages of AD is very limited. In order to determine effective endpoints for possible therapies, a number of quantitative surrogate markers of disease progression have been suggested, including biochemical and imaging biomarkers. The dynamics of these various surrogate markers over time, particularly in relation to disease development, are, however, not well characterized. We reviewed the literature for studies that measured cerebrospinal fluid or plasma amyloid-β and tau, or took magnetic resonance image or fluorodeoxyglucose/Pittsburgh compound B-positron electron tomography scans, in longitudinal cohort studies. We summarized the properties of the major cohort studies in various countries, commonly used diagnosis methods and study designs. We have concluded that additional studies with repeat measures over time in a representative population cohort are needed to address the gap in knowledge of AD progression. Based on our analysis, we suggest directions in which research could move in order to advance our understanding of this complex disease, including repeat biomarker measurements, standardization and increased sample sizes.
- Subjects :
- 0301 basic medicine
Oncology
MILD COGNITIVE IMPAIRMENT
Disease
Global Health
HIPPOCAMPAL ATROPHY
0302 clinical medicine
TENSOR-BASED MORPHOMETRY
WHITE-MATTER HYPERINTENSITIES
General Neuroscience
PLASMA AMYLOID-BETA
General Medicine
Alzheimer's disease
Psychiatry and Mental health
Clinical Psychology
biomarker
Biomarker (medicine)
Life Sciences & Biomedicine
Alzheimer’s disease
Research Article
medicine.drug
Cohort study
cross-sectional
medicine.medical_specialty
longitudinal
Neuroimaging
MULTICENTER CLINICAL-TRIALS
03 medical and health sciences
POSITRON-EMISSION-TOMOGRAPHY
CEREBROSPINAL-FLUID
Alzheimer Disease
BRAIN VOLUME CHANGES
Internal medicine
medicine
Humans
Dementia
Fluorodeoxyglucose
Science & Technology
Neurology & Neurosurgery
business.industry
Clinical study design
Neurosciences
Alzheimer's disease biomarkers
1103 Clinical Sciences
1702 Cognitive Science
Gold standard (test)
PITTSBURGH COMPOUND-B
medicine.disease
030104 developmental biology
Neurosciences & Neurology
Geriatrics and Gerontology
1109 Neurosciences
business
Biomarkers
030217 neurology & neurosurgery
dementia
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....b0eed503acaa0b8c8fcb6d73e1f3f757
- Full Text :
- https://doi.org/10.3233/jad-170261