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Antibiotic Cycling Reverts Extensive Drug Resistance in Burkholderia multivorans
- Source :
- Antimicrob Agents Chemother
- Publication Year :
- 2021
-
Abstract
- Antibiotic collateral sensitivity, in which acquired resistance to one drug leads to decreased resistance to a different drug, occurs in Burkholderia multivorans . Here, we observed that treatment of extensively drug-resistant variants from a cystic fibrosis (CF) sputum sample with either meropenem or sulfamethoxazole-trimethoprim, depending on past resistance phenotypes, resulted in increased sensitivity to five different classes of antibiotics. We further identified mutations, including putative resistance-nodulation-division efflux pump regulators and uncharacterized pumps, that may be involved in this phenotype in B. multivorans .
- Subjects :
- medicine.drug_class
Burkholderia
Antibiotics
Drug Resistance
Microbial Sensitivity Tests
Biology
Meropenem
Cystic fibrosis
Microbiology
03 medical and health sciences
Antibiotic resistance
medicine
Humans
Pharmacology (medical)
Mechanisms of Action: Physiological Effects
030304 developmental biology
Pharmacology
0303 health sciences
030306 microbiology
Burkholderia cepacia complex
Burkholderia multivorans
Burkholderia Infections
biology.organism_classification
medicine.disease
Phenotype
Anti-Bacterial Agents
Infectious Diseases
Efflux
medicine.drug
Subjects
Details
- ISSN :
- 10986596
- Volume :
- 65
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....b0f4cc3fb06b99e0de0e841c89a47229