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Ionic liquid based vortex assisted liquid–liquid microextraction combined with liquid chromatography mass spectrometry for the determination of bisphenols in thermal papers with the aid of response surface methodology
- Source :
- Journal of Chromatography A. 1509:35-42
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- A sensitive, rapid and efficient ionic liquid-based vortex assisted liquid-liquid microextraction (IL-VALLME) with Liquid Chromatography Mass spectrometry (LC-MS/MS) method is proposed for the determination of bisphenols in thermal paper. Extraction factors were systematically optimized by response surface methodology. Experimental factors showing significant effects on the analytical responses were evaluated using design of experiment. The limit of detection for Bisphenol-A (BPA) and Bisphenol-S (BPS) in thermal paper were 1.25 and 0.93μgkg-1 respectively. The dynamic linearity range for BPA was between 4 and 100μgkg-1 and the determination of coefficient (R2) was 0.996. The values of the same parameters were 3-100μgkg-1 and 0.998 for BPS. The extraction recoveries of BPA and BPS in thermal paper were 101% and 99%. Percent relative standard deviation (% RSD) for matrix effect and matrix match effects were not more than 10%, for both bisphenols. The proposed method uses a statistical approach for the analysis of bisphenols in environmental samples, and is easy, rapid, requires minimum organic solvents and efficient.
- Subjects :
- Paper
Liquid Phase Microextraction
Bisphenol
Analytical chemistry
Ionic Liquids
010501 environmental sciences
01 natural sciences
Biochemistry
Analytical Chemistry
Matrix (chemical analysis)
chemistry.chemical_compound
Phenols
Tandem Mass Spectrometry
Liquid chromatography–mass spectrometry
Sulfones
Response surface methodology
Benzhydryl Compounds
Chromatography, High Pressure Liquid
0105 earth and related environmental sciences
Detection limit
Chromatography
Chemistry
010401 analytical chemistry
Organic Chemistry
Extraction (chemistry)
General Medicine
Thermal paper
0104 chemical sciences
Ionic liquid
Subjects
Details
- ISSN :
- 00219673
- Volume :
- 1509
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography A
- Accession number :
- edsair.doi.dedup.....b11892b53bcfb2902fdca57042b8d025