Back to Search
Start Over
Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma
- Source :
- Cancer Biology & Therapy. 16:1042-1046
- Publication Year :
- 2015
- Publisher :
- Informa UK Limited, 2015.
-
Abstract
- Circulating microRNAs (miRNAs) are emerging as promising non-invasive biomarkers for human cancer. Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy worldwide, but its overall survival has remained unchanged in the past 3 decades. Biomarkers for evaluating efficacy of cancer therapy are urgently needed. To explore circulating miRNAs as cancer therapy biomarkers, we initially identified that 8 miRNAs were distinctly dysregulated in cancerous tissues compared with adjacent non-cancerous counterparts from 16 patients, using microarray and real-time PCR. Based on this discovery, the comparison study was performed between pre- and 6 months post-operative paired plasma samples on 9 patients. MiR-99a, which was down-regulated in cancerous tissues, was significantly increased in plasma after operation. Meanwhile, oncomiR miR-21 and miR-223 that were up-regulated in cancerous tissues, were significantly reduced in post-operative plasma samples. We firstly report the significant changes of miR-99a in plasma of HNSCC patients after surgery. Furthermore, plasma miR-223 was inversely increased in a patient whose cancer relapsed within 6 months after operation. We conclude that these circulating miRNAs may serve as biomarkers to evaluate the efficacy of therapy and the prognosis of HNSCC.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Microarray
Malignancy
mir-223
Internal medicine
Biomarkers, Tumor
medicine
Humans
Postoperative Period
Aged
Oligonucleotide Array Sequence Analysis
Aged, 80 and over
Pharmacology
Reverse Transcriptase Polymerase Chain Reaction
business.industry
Gene Expression Profiling
Cancer
Middle Aged
Oncomir
Prognosis
medicine.disease
Head and neck squamous-cell carcinoma
Gene Expression Regulation, Neoplastic
MicroRNAs
Circulating MicroRNA
Head and Neck Neoplasms
Carcinoma, Squamous Cell
Molecular Medicine
Biomarker (medicine)
Female
business
Research Paper
Subjects
Details
- ISSN :
- 15558576 and 15384047
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Cancer Biology & Therapy
- Accession number :
- edsair.doi.dedup.....b1479954882b6c4637209ed49d40d40c