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Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV
- Source :
- Bioorganic & Medicinal Chemistry, SEDICI (UNLP), Universidad Nacional de La Plata, instacron:UNLP, Bioorganic & Medicinal Chemistry; Vol 21
- Publication Year :
- 2012
-
Abstract
- A set of sulfamides and sulfamates were synthesized and tested against several isoforms of carbonic anhydrase: CA I, CA II, CA VII, CA XII and CA XIV. The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki<br />Facultad de Ciencias Exactas
- Subjects :
- Gene isoform
Carbonic Anhydrase I
Molecular model
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
010402 general chemistry
01 natural sciences
Biochemistry
Isozyme
Molecular dynamic simulations
Carbonic Anhydrase II
Docking
chemistry.chemical_compound
Carbonic anhydrase
Catalytic Domain
Drug Discovery
Humans
Inhibition pattern
Carbonic Anhydrase Inhibitors
Molecular Biology
Sulfamide
Carbonic Anhydrases
Sulfonamides
Binding Sites
biology
010405 organic chemistry
Chemistry
Otras Ciencias Químicas
Organic Chemistry
Ciencias Químicas
Química
0104 chemical sciences
3. Good health
Molecular Docking Simulation
Docking (molecular)
biology.protein
Molecular Medicine
Sulfamides
Selectivity
CIENCIAS NATURALES Y EXACTAS
Protein Binding
Subjects
Details
- ISSN :
- 14643391
- Volume :
- 21
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry
- Accession number :
- edsair.doi.dedup.....b1b397c16085523e5a61138d98e707f5