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Nose to Brain Delivery: New Trends in Amphiphile-Based 'Soft' Nanocarriers
- Source :
- Scopus-Elsevier
- Publication Year :
- 2015
- Publisher :
- Bentham Science Publishers Ltd., 2015.
-
Abstract
- The aim of the present paper is to highlight the potential of nasal mucosa as an administration route for targeting the central nervous system, in particular, the brain. Among the formulation strategies for enhance nose to brain drug delivery, the use of colloidal carriers has became a revolutionary approach. These systems should be able to entrap drugs in the desired amount, to penetrate through anatomical barriers, to efficiently release the loaded drugs in the site of action and moreover to show a good physicochemical, biological stability and good biocompatibility. The use of vesicular systems (liposomes and niosomes) together with the use of micelles, in nose to brain delivery are here presented. Vesicle structure is characterized by the presence of a hydrophobic bilayer and an aqueous core that is absent in micelles. Amphiphilic molecules are responsible for soft nanocarriers formation, in particular: liposomes are formed by phospholipids, while niosomes by non-ionic surfactant and micelles by amphiphilic polymers.
- Subjects :
- Polymers
Chemistry, Pharmaceutical
Nanotechnology
Micelle
Surface-Active Agents
Drug Delivery Systems
Drug Discovery
Amphiphile
Animals
Humans
Tissue Distribution
Niosome
Administration, Intranasal
Pharmacology
Drug Carriers
Liposome
Chemistry
Brain
Pharmaceutical Preparations
Liposomes
Drug delivery
Nanoparticles
Nasal administration
Nanocarriers
Drug carrier
Hydrophobic and Hydrophilic Interactions
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....b1c8dcc763e5db2fe3de36ff72391dc7